On the nature of keloid and hypertrophic scars

“…In the majority of cases, hypertrophic scarring develops in wounds at anatomic locations with high tension, such as shoulders, neck, presternum, knees and ankles (9,12,13), whereas anterior chest, shoulders, earlobes, upper arms and cheeks have a higher predilection for keloid formation. Eyelids, cornea, palms, mucous membranes, genitalia and soles are generally less affected (14).…”

Section: Clinical Characteristicsmentioning

confidence: 99%

“…Eyelids, cornea, palms, mucous membranes, genitalia and soles are generally less affected (14). Keloids tend to recur following excision, whereas new hypertrophic scar formation is rare after excision of the original hypertrophic scar (13,15).…”

Section: Clinical Characteristicsmentioning

confidence: 99%

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Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Gauglitz

Körting

Pavicic

et al. 2010

Mol Med

1,178

1,012

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Excessive scars form as a result of aberrations of physiologic wound healing and may arise following any insult to the deep dermis. By causing pain, pruritus and contractures, excessive scarring significantly affects the patient's quality of life, both physically and psychologically. Multiple studies on hypertrophic scar and keloid formation have been conducted for decades and have led to a plethora of therapeutic strategies to prevent or attenuate excessive scar formation. However, most therapeutic approaches remain clinically unsatisfactory, most likely owing to poor understanding of the complex mechanisms underlying the processes of scarring and wound contraction. In this review we summarize the current understanding of the pathophysiology underlying keloid and hypertrophic scar formation and discuss established treatments and novel therapeutic strategies.

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“…scars and exceeds in size by indefinite progression (8,(33)(34)(35)(36). As a result, keloids are characterized by exuberant, erythematous scars, which grow beyond the confines of the original wounds and rarely regress over time (9) (Fig.…”

Section: Keloids Versus Hypertrophic Scarsmentioning

confidence: 99%

Keloids: Current concepts of pathogenesis (Review)

Bran¹

2009

Int J Mol Med

193

208

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Abstract. Excess scar formation occurs after dermal injury as a result of abnormal wound healing. Hypertrophic scars and keloids both represent fibrotic skin conditions which can be very difficult, even frustrating, to treat. Identification of differences between hypertrophic scars, keloids and normal scars are a prerequisite for finding the correct therapeutical concept. Despite the relatively high prevalence of keloids in the general population, the mechanisms underlying keloid formation are only partially understood. This fact is reflected in the multiple treatment modalities, of which no single treatment has proven to be widely effective. Advances in our understanding of the wound healing process reveal new pathophysiological concepts for keloid formation. Our article presents an overview on physiological wound healing and the pathogenesis of scar formation, differentiates keloids from hypertrophic scars and reviews current hypotheses for keloid formation. This information might assist in deciphering the complexity of keloid pathogenesis and help in the development of an efficacious therapeutical strategy.

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On the nature of keloid and hypertrophic scars

Cited by 161 publications

References 11 publications

What factors affect the quality of life of patients with keloids?

What factors affect the quality of life of patients with keloids?

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Keloids: Current concepts of pathogenesis (Review)

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