On the Neurogenesis of So-Called Granular Cell Myoblastoma

Fust, John A.; Custer, R. Philip

doi:10.1093/ajcp/19.6.522

Cited by 209 publications

(23 citation statements)

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“…Abrikossoff named the lesion "myoblastic myoma" because he thought that the tumor originated from striated muscle. 1 After the original description, GCT has been designated by a plethora of terms, including granular cell myoblastoma, 2-8 granular cell histiocytoma, 9 granular cell neuroma, 10 granular cell neurofibroma, 11 and granular cell schwannoma. 10 Nowadays, the preferred designation for this neoplasm is GCT.…”

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confidence: 99%

Oculomotor Disturbances Due to Granular Cell Tumor

Ribeiro

Chahud

Cruz

2012

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Primary granular cell tumor of the orbit is a rare type of neoplasm. The tumor is frequently associated with extraocular muscles, and eye motility limitation is an unavoidable complication after its surgical removal. The objective of the present article is to review the literature on primary granular cell tumors of the orbit and to report a case of this uncommon neoplasia. Granular cell tumor is a benign lesion encountered in most cases (58.3%) in the inferior aspect of the orbit. Extraocular muscle involvement occurs in 72.2% of the patients, and diplopia is present in 77.1% of the cases. The inferior and medial recti are the most affected muscles (38.5% and 26.9%, respectively). Surgical excision is the only modality of treatment, but diplopia persists in 73.3% of the cases. In conclusion, granular cell tumor is a benign lesion but involves a high rate of extraocular muscle morbidity.

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confidence: 99%

Oculomotor Disturbances Due to Granular Cell Tumor

Ribeiro

Chahud

Cruz

2012

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…Additionally, it is clearly known that, when there is damage to the myelin sheath, the myelin enter into a process of disintegration and is phagocytosed initially by Schwann cells, and later by macrophages. (17,18) The p75 positive expression has been reported as an important event that can be observed in the main neural tumors and other benign soft tumors. The importance of its expression is based on the relation between p75 and the nerve growth factor (NGF).…”

Section: Discussionmentioning

confidence: 99%

The neural histogenetic origin of the oral granular cell tumor: An immunohistochemical evidence

Ra¹,

Ms²,

Cortes³

et al. 2011

Med Oral

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Aims: Granular cell tumor (GCT) is a rare neoplasm that can appear in any site of the body, but most are located intraorally. Its histogenetic origin remains unclear. This report analyzes the immunoprofile of 15 cases of granular cell tumors, occurring in 13 women and 2 men and the lesions were located on the tongue or upper lip. Patient age ranged from 7 to 52. Methods: The patients demographic data and the cytological and architectural features of the lesions were analyzed in oral GCTs (n = 15). The lesions were also submitted to a panel of immunohistochemical stains with antibodies against S-100, p75, NSE, CD-68, Ki-67, Synaptofisin, HHF-35, SMA, EMA, Chromogranin, Progesterone, Androgen and Estrogen. Results: Among the fifteen cases analyzed, the most common location was the tongue (84.6%). Histologically, the tumors exhibited cellular proliferation composed mainly by polygonal cells presenting an abundant granular eosinophilic cytoplasm. The nuclei were central, and the cell membranes were moderately clear. No mitotic figures were observed. The immunohistochemical analysis showed positivity in all cases for S-100, p75, NSE and CD-68, and no immunoreactivity for Ki-67, Synaptofisin, HHF-35, SMA, EMA, Chromogranin, Progesterone, Androgen and Estrogen. Conclusion: The immunoprofile of granular cell tumors showed nerve sheath differentiation -lending support to their neural origin -and helping to establish a differential diagnosis between this lesion and other oral granular cell tumors, whether benign or malignant.

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“…Other theories regarding its histogenesis include a fibroblastic [5], a storage-cell [11,12] and an epithelial origin [17]. Recently some investigators have suggested the concept that granular cell tumors are of a neural origin [3,[13][14][15][16][28][29][30], especially Schwann cells [13][14][15][16]. This concept was based on light and electron microscopic observations showing that the tumor cells were within peripheral nerve sheaths.…”

Section: Discussionmentioning

confidence: 99%