On the neurological roles of chondroitin sulfate and glucosamine sulfate: a systematic analysis

Громова, О. А.; Torshin, I. Yu.; Семенов, В. А.; Stakhovskaya, L. I.; Рудаков, К. В.

doi:10.14412/2074-2711-2019-3-137-143

Cited by 9 publications

(2 citation statements)

References 43 publications

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“…Specifically, studies have reported the isolation of CS from the blackmouth catshark (Galeus melastomus) [118], corb (Sciaena umbra) skin [135], and various shark and other fish cartilage [136]. Experimental researches have indicated the benefits of CS in the therapy of neurodegenerative diseases [137], with one study reporting the neuroprotective effects of CS against advanced glycation end products-induced toxicity, which has been linked to amyloid-β aggregation, oxidative stress, and inflammation [138]. Moreover, low molecular weight CS and selenium-CS nanoparticles have been shown to protect SH-SY5Y cells by inhibiting amyloid-β aggregation, decreasing reactive oxygen species and malondialdehyde levels, and increasing glutathione peroxidase levels [139,140].…”

Section: Marine Glycosaminoglycans For Neuroprotectionmentioning

confidence: 99%

Marine Biocompounds for Neuroprotection—A Review

2020

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While terrestrial organisms are the primary source of natural products, recent years have witnessed a considerable shift towards marine-sourced biocompounds. They have achieved a great scientific interest due to the plethora of compounds with structural and chemical properties generally not found in terrestrial products, exhibiting significant bioactivity ten times higher than terrestrial-sourced molecules. In addition to the antioxidant, anti-thrombotic, anti-coagulant, anti-inflammatory, anti-proliferative, anti-hypertensive, anti-diabetic, and cardio-protection properties, marine-sourced biocompounds have been investigated for their neuroprotective potential. Thus, this review aims to describe the recent findings regarding the neuroprotective effects of the significant marine-sourced biocompounds.

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Section: Marine Glycosaminoglycans For Neuroprotectionmentioning

confidence: 99%

Marine Biocompounds for Neuroprotection—A Review

2020

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“…Участие ХС/ГС в поддержании структуры аксонов, соединительнотканных перинейрональных сетей и др. было рассмотрено нами ранее [15].…”

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Systematic analysis of the molecular pathophysiology of tenosynovitis: promise for using chondroitin sulfate and glucosamine sulfate

Torshin

Громова

Лила

et al. 2020

RJTAO

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Хондропротекторы глюкозамина сульфат (ГС) и хондроитина сульфат (ХС) проявляют комплексное противовоспалительное действие и поэтому могут использоваться в терапии многих заболеваний, коморбидных остеоартриту (ОА). Цель исследования -систематический анализ взаимосвязи молекулярной патофизиологии тендовагинита и потенциальных механизмов патогенетического действия ХС/ГС при этом заболевании. Материал и методы. Проведена систематизация текстов 15 097 публикаций посредством современных методов анализа больших данных, развиваемых в рамках топологического и метрического подходов к задачам распознавания/классификации. Результаты и обсуждение. Получена карта молекулярной патофизиологии тендовагинита, включающая 15 молекулярных механизмов и 27 коморбидных заболеваний. Выделены механизмы, посредством которых ХС/ГС могут противодействовать развитию тендовагинита: ингибирование эффектов провоспалительных цитокинов, в частности интерлейкина (ИЛ) 1, ИЛ8, γ-интерферона, фактора некроза опухолей α, а также воспалительного белка макрофагов MCP1, инфламмасомы NLRP3, сигнальных путей NF-κB и JAK/STAT, О-глюкозаминирования белков протеома. До настоящего времени не проводилось рандомизированных клинических или когортных (неинтервенционных) исследований эффектов ХС/ГС у пациентов с тендовагинитом и коморбидными заболеваниями. Однако в доклинических исследованиях ГС и ХС при лечении тендинопатий проявляли обезболивающие свойства, уменьшали хроническое воспаление, отек, улучшали вызревание коллагеновых пучков и, следовательно, механические свойства соединительной ткани сухожилий и связок. Заключение. Результаты экспериментальных и клинических исследований указывают на перспективность использования при тендовагините препаратов ХС/ГС на основе фармацевтических субстанций с высокой степенью стандартизации.

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Fish supportive, connective and integumentary tissues in food biotechnology

Zemlyakova

Ключко

Орлов

et al. 2021

IOP Conf. Ser.: Earth Environ. Sci.

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The relevance of the study is due to the insufficient use of the biopotential of the supportive, connective and integumentary tissues of fish (bones, cartilage, fins, heads, scales, skin), which are considered by many scientists as sources of valuable biologically active substances that can be used as functional ingredients in food biotechnology. Collagen and its hydrolysis products, chondroitin sulfate, glycosamine, hyaluronic acid, minerals (calcium, phosphorus, potassium, magnesium, etc.) are the most important components in maintaining human health and, especially, in the prevention and treatment of diseases of the musculoskeletal system. Therefore, the use of hydrolyzed fish tissues as sources of biologically active substances is promising. The biotechnological method of raw material degradation (enzymatic hydrolysis) is the most appropriate, allowing not only to preserve the biopotential of the native tissues, but also to ensure the reliability and sustainability of the production process. The article presents the results of the study of the chemical composition of fish supportive, connective and integumentary tissues, describes the technologies for obtaining new products using these biologically active substances generated by enzymatic hydrolysis.

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On the neurological roles of chondroitin sulfate and glucosamine sulfate: a systematic analysis

Cited by 9 publications

References 43 publications

Marine Biocompounds for Neuroprotection—A Review

Marine Biocompounds for Neuroprotection—A Review

Systematic analysis of the molecular pathophysiology of tenosynovitis: promise for using chondroitin sulfate and glucosamine sulfate

Fish supportive, connective and integumentary tissues in food biotechnology

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