On the Neuroprotective Effects of Naringenin: Pharmacological Targets, Signaling Pathways, Molecular Mechanisms, and Clinical Perspective

Nouri, Zeinab; Fakhri, Sajad; El-Senduny, Fardous F.; Sanadgol, Nima; Ghani, Ghada E. Abd El; Farzaei, Mohammad Hosein; Chen, Jen‐Tsung

doi:10.3390/biom9110690

Cited by 101 publications

(67 citation statements)

References 190 publications

(213 reference statements)

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“…Naringenin is the predominant flavanone in grapefruit and possesses antidiabetic, antioxidant and memory improving properties. It positively stimulated the serotonergic neurotransmission in the brain by enhancing 5-HT synthesis [ 84 , 85 ]. In rats exposed to chronic mild stress apigenin, another compound belonging to the flavone class, attenuated the altered 5-HT level in the prefrontal cortex, hypothalamus, hippocampus and nucleus accumbens [ 86 ].…”

Section: Biogenic Amines and Polyphenolsmentioning

confidence: 99%

Neuroprotective Polyphenols: A Modulatory Action on Neurotransmitter Pathways

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Rzajew

Radzik

et al. 2020

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Background: Balance in neurotransmission is essential for the proper functioning of the nervous system and even a small, but prolonged disturbance, can induce the negative feedback mechanisms leading to various neuropathologies. Neurodegenerative and mood disorders such as Alzheimer’s, Parkinson’s or affective disorders are increasing medical and social problems. Among the wide spectrum of potentially destructive events, oxidative stress and disrupted metabolism of some neurotransmitters such as acetylcholine, GABA, glutamate, serotonin or dopamine appear to play a decisive role. Biologically active plant polyphenols have been shown to exert a positive impact on the function of the central nervous system by modulation of metabolism and the action of some neurotransmitters. Methods: Based on published research, the pharmacological activities of some naturally occurring polyphenols have been reviewed, with a focus on their potential therapeutic importance in the regulation of neurotransmitter systems. Results: Phytochemicals can be classified into several groups and most of them possess anticancer, antioxidative, anti-inflammatory and neuroprotective properties. They can also modulate the metabolism or action of some neurotransmitters and/or their receptors. Based on these properties, phytochemicals have been used in traditional medicine for ages, although it was focused mainly on treating symptoms. However, growing evidence indicates that polyphenols may also prevent or slow neurological diseases. Conclusion: Phytochemicals seem to be less toxic than synthetic drugs and they can be a safer alternative for currently used preparations, which exert adverse side effects. The neuroprotective actions of some plant polyphenols in the regulation of neurotransmitters metabolism, functioning of neurotransmitters receptors and antioxidative defense have potential therapeutic applications in various neurodegenerative disorders.

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Section: Biogenic Amines and Polyphenolsmentioning

confidence: 99%

Neuroprotective Polyphenols: A Modulatory Action on Neurotransmitter Pathways

Rębas

Rzajew

Radzik

et al. 2020

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“…Naringenin is a natural flavanone endowed with neuroprotective properties [ 121 ]. The molecule protected culture neurons against hypoxic injury by reducing oxidative stress and mitochondrial dysfunction via activation of Nrf2 signaling [ 122 , 123 ].…”

Section: Polyphenols and Stroke: Results From Preclinical Stroke Mmentioning

confidence: 99%

From Preclinical Stroke Models to Humans: Polyphenols in the Prevention and Treatment of Stroke

et al. 2020

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Polyphenols are an important family of molecules of vegetal origin present in many medicinal and edible plants, which represent important alimentary sources in the human diet. Polyphenols are known for their beneficial health effects and have been investigated for their potential protective role against various pathologies, including cancer, brain dysfunctions, cardiovascular diseases and stroke. The prevention of stroke promoted by polyphenols relies mainly on their effect on cardio- and cerebrovascular systems. However, a growing body of evidence from preclinical models of stroke points out a neuroprotective role of these molecules. Notably, in many preclinical studies, the polyphenolic compounds were effective also when administered after the stroke onset, suggesting their possible use in promoting recovery of patients suffering from stroke. Here, we review the effects of the major polyphenols in cellular and in vivo models of both ischemic and hemorrhagic stroke in immature and adult brains. The results from human studies are also reported.

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“…Naringenin (and its precursor naringin), is a flavanone, present in citrus and grapefruits, involved in different signaling pathways mainly related to neuroprotection [ 193 ]. Naringin attenuates inflammatory response (its potential to alleviate COVID-19 symptoms has recently been reported [ 194 ]), and it is believed to show anti-AChE activity as well [ 195 ].…”

Section: Chemical Characterization Of Nootropic Bioactive Compoundmentioning

confidence: 99%

Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction

et al. 2021

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Late-life mild cognitive impairment and dementia represent a significant burden on healthcare systems and a unique challenge to medicine due to the currently limited treatment options. Plant phytochemicals have been considered in alternative, or complementary, prevention and treatment strategies. Herbals are consumed as such, or as food supplements, whose consumption has recently increased. However, these products are not exempt from adverse effects and pharmacological interactions, presenting a special risk in aged, polymedicated individuals. Understanding pharmacokinetic and pharmacodynamic interactions is warranted to avoid undesirable adverse drug reactions, which may result in unwanted side-effects or therapeutic failure. The present study reviews the potential interactions between selected bioactive compounds (170) used by seniors for cognitive enhancement and representative drugs of 10 pharmacotherapeutic classes commonly prescribed to the middle-aged adults, often multimorbid and polymedicated, to anticipate and prevent risks arising from their co-administration. A literature review was conducted to identify mutual targets affected (inhibition/induction/substrate), the frequency of which was taken as a measure of potential interaction. Although a limited number of drugs were studied, from this work, interaction with other drugs affecting the same targets may be anticipated and prevented, constituting a valuable tool for healthcare professionals in clinical practice.

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On the Neuroprotective Effects of Naringenin: Pharmacological Targets, Signaling Pathways, Molecular Mechanisms, and Clinical Perspective

Cited by 101 publications

References 190 publications

Neuroprotective Polyphenols: A Modulatory Action on Neurotransmitter Pathways

Neuroprotective Polyphenols: A Modulatory Action on Neurotransmitter Pathways

From Preclinical Stroke Models to Humans: Polyphenols in the Prevention and Treatment of Stroke

Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction

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