We prove the nonvanishing of the twisted central critical values of a class of automorphic L-functions for twists by all but finitely many unitary characters in particular infinite families. While this paper focuses on L-functions associated to certain automorphic representations of unitary groups, it illustrates how decades-old nonarchimedean methods from Iwasawa theory can be combined with the output of new machinery to achieve broader nonvanishing results. In an appendix, which concerns an intermediate step, we also outline how to extend relevant prior computations for p-adic Eisenstein series and L-functions on unitary groups to the case where primes dividing p merely needs to be unramified (whereas prior constructions required p to split completely) in the associated reflex field.