In this work, the existence and uniqueness solution of the fractional nonlinear mixed integro-differential equation (FrNMIoDE) is guaranteed with a general discontinuous kernel based on position and time-space L2Ω×C0,T, T<1. The FrNMIoDE conformed to the Volterra-Hammerstein integral equation (V-HIE) of the second kind, after applying the characteristics of a fractional integral, with a general discontinuous kernel in position for the Hammerstein integral term and a continuous kernel in time to the Volterra integral (VI) term. Then, using a separation technique methodology, we developed HIE, whose physical coefficients were time-variable. By examining the system’s convergence, the product Nystrom technique (PNT) and associated schemes were employed to create a nonlinear algebraic system (NAS).