On the optimal choice of the exposure conditions and the nanoparticle features in magnetic nanoparticle hyperthermia

Abstract

By exploiting the proposed criterion a study of the clinical scalability of the therapeutic approach is presented.

A review on hyperthermia via nanoparticle-mediated therapy

“…Their model was validated by considering the clinically relevant ranges for the infusion parameters. The research group led by Bellizzi [54] presented the optimisation criterion for the choice of magnetic nanoparticle hyperthermia conditions and later provided the numerical assessment with reference to the challenging and clinically relevant case of brain tumours, by using a 3D model of the human head [55]. The two important features of their study were the minimised magnetic nanoparticles dosage and the controlled temperature rise to enable efficient and safer treatment.…”

Improved efficiency of heat generation in nonlinear dynamics of magnetic nanoparticles

“…The unique feature of magnetic nanoparticle hyperthermia is that the energy is transported in the body by means of an ac magnetic field. At present the clinical application is partly limited due to the efficacy of the heat transfer and the poor controllability of temperature parameters [5]. Thus, the study of relaxation mechanisms of magnetic nanoparticles is a very active research field, both in its theoretical and material-science aspects.…”

Broadband spectroscopy of the electromagnetic properties of aqueous ferrofluids for biomedical applications

“…Moreover, the interaction between MNP's and the impinging RF EMF has been of interest as a therapeutic agent in anticancer hyperthermia treatments. Indeed, to increase the temperature of the tumor above the therapeutic threshold, anticancer Magnetic Fluid Hyperthermia [1][2][3] exploits MNP's to convert the energy of the applied RF magnetic field (MF) into heat [4]. In a different application, the capability of MNP's of absorbing the energy of a MW radiation has been exploited in a novel and more efficient method of microwave-assisted protein digestion [5].…”