On the pathogenesis of preleukemic myelodysplastic syndromes

Fohlmeister, I; Schaefer, Hans-Eckart; Fischer, R.

doi:10.1007/bf00406245

Cited by 10 publications

(1 citation statement)

References 24 publications

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“…Examples of compound-associated poikilocytosis have also been reported. Single-pulse dosing of rats with dimethylbenz(a)anthracene may produce a preleukemic myelodysplastic syndrome associated with anisocytosis, poikilocytosis, nuclear deformity, atypical mitoses, and megaloblastoid change (Fohlmeister et al 1982). Furthermore, as discussed by Travlos, SDD administration to rats may also produce poikilocytosis and microcytosis (Bucher 2007).…”

Section: Review Of Microcytosismentioning

confidence: 99%

Proceedings of the 2011 National Toxicology Program Satellite Symposium

et al. 2011

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The 2011 annual National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri,” was held in Denver, Colorado in advance of the Society of Toxicologic Pathology’s 30th Annual Meeting. The goal of the NTP Symposium is to present current diagnostic pathology or nomenclature issues to the toxicologic pathology community. This article presents summaries of the speakers’ presentations, including diagnostic or nomenclature issues that were presented, along with select images that were used for audience voting or discussion. Some lesions and topics covered during the symposium include: proliferative lesions from various fish species including ameloblastoma, gas gland hyperplasia, nodular regenerative hepatocellular hyperplasia, and malignant granulosa cell tumor; spontaneous cystic hyperplasia in the stomach of CD1 mice and histiocytic aggregates in the duodenal villous tips of treated mice; an olfactory neuroblastoma in a cynomolgus monkey; various rodent skin lesions, including follicular parakeratotic hyperkeratosis, adnexal degeneration, and epithelial intracytoplasmic accumulations; oligodendroglioma and microgliomas in rats; a diagnostically challenging microcytic, hypochromic, responsive anemia in rats; a review of microcytes and microcytosis; nasal lesions associated with green tea extract and Ginkgo biloba in rats; corneal dystrophy in Dutch belted rabbits; valvulopathy in rats; and lymphoproliferative disease in a cynomolgus monkey.

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Section: Review Of Microcytosismentioning

confidence: 99%

Proceedings of the 2011 National Toxicology Program Satellite Symposium

et al. 2011

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Summary of animal models of myelodysplastic syndrome

Yang

et al. 2021

Anim Models and Exp Med

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Myelodysplastic syndrome (MDS) is a malignant tumor of the hematological system characterized by long‐term, progressive refractory hemocytopenia. In addition, the risk of leukemia is high, and once it develops, the course of acute leukemia is short with poor curative effect. Animal models are powerful tools for studying human diseases and are highly effective preclinical platforms. Animal models of MDS can accurately show genetic aberrations and hematopoietic clone phenotypes with similar cellular features (such as impaired differentiation and increased apoptosis), and symptoms can be used to assess existing treatments. Animal models are also helpful for understanding the pathogenesis of MDS and its relationship with acute leukemia, which helps with the identification of candidate genes related to the MDS phenotype. This review summarizes the current status of animal models used to research myelodysplastic syndrome (MDS).

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Novel spontaneous myelodysplastic syndrome mouse model

Cao

et al. 2021

Anim Models and Exp Med

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Background Myelodysplastic syndrome (MDS) is a group of disorders involving hemopoietic dysfunction leading to leukemia. Although recently progress has been made in identifying underlying genetic mutations, many questions still remain. Animal models of MDS have been produced by introduction of specific mutations. However, there is no spontaneous mouse model of MDS, and an animal model to simulate natural MDS pathogenesis is urgently needed. Methods In characterizing the genetically diverse mouse strains of the Collaborative Cross (CC) we observed that one, designated JUN, had abnormal hematological traits. This strain was thus further analyzed for phenotypic and pathological identification, comparing the changes in each cell population in peripheral blood and in bone marrow. Results In a specific‐pathogen free environment, mice of the JUN strain are relatively thin, with healthy appearance. However, in a conventional environment, they become lethargic, develop wrinkled yellow hair, have loose and light stools, and are prone to infections. We found that the mice were cytopenic, which was due to abnormal differentiation of multipotent bone marrow progenitor cells. These are common characteristics of MDS. Conclusions A mouse strain, JUN, was found displaying spontaneous myelodysplastic syndrome. This strain has the advantage over existing models in that it develops MDS spontaneously and is more similar to human MDS than genetically modified mouse models. JUN mice will be an important tool for pathogenesis research of MDS and for evaluation of new drugs and treatments.

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On the pathogenesis of preleukemic myelodysplastic syndromes

Cited by 10 publications

References 24 publications

Proceedings of the 2011 National Toxicology Program Satellite Symposium

Proceedings of the 2011 National Toxicology Program Satellite Symposium

Summary of animal models of myelodysplastic syndrome

Novel spontaneous myelodysplastic syndrome mouse model

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