2024
DOI: 10.3390/ijms25073590
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On the Possibility of Using 5-Aminolevulinic Acid in the Light-Induced Destruction of Microorganisms

Anna Zdubek,
Irena Maliszewska

Abstract: Antimicrobial photodynamic inactivation (aPDI) is a method that specifically kills target cells by combining a photosensitizer and irradiation with light at the appropriate wavelength. The natural amino acid, 5-aminolevulinic acid (5-ALA), is the precursor of endogenous porphyrins in the heme biosynthesis pathway. This review summarizes the recent progress in understanding the biosynthetic pathways and regulatory mechanisms of 5-ALA synthesis in biological hosts. The effectiveness of 5-ALA-aPDI in destroying v… Show more

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Cited by 2 publications
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