On the Post-Compaction Evolution of Tensile Strength of Sodium Chloride-Starch Mixture Tablets

Radojevic, Jovana; Zavaliangos, Antonios

doi:10.1016/j.xphs.2017.04.079

Cited by 10 publications

(6 citation statements)

References 51 publications

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“…46 On the contrary, the dissolution−precipitation of NaCl−NaCl contacts could generate tensile stresses and weaken the tablet matrix. 44 At 5%, w/w NaCl, the amount of NaCl may not be sufficient to cause significant weakening of the tablet matrix during post-compaction storage. The decrease in the tensile strength of tablets containing Mg(NO 3 ) 2 •6H 2 O during post-compaction storage could be attributed to the deliquescence of Mg(NO 3 ) 2 •6H 2 O.…”

Section: Discussionmentioning

confidence: 99%

“…The locally dissolved NaCl particles smooth surface cracks and crystal flaws, reducing stress concentrators in the tablet matrix . The dissolved NaCl particles could precipitate at particle-to-particle contact points, forming stronger tablets . The dissolution of NaCl particles could also facilitate the rearrangement of the materials, resulting in tablets with lower porosity.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, moisture could facilitate stronger interparticulate bonding by hydrogen bonding . On the contrary, the dissolution–precipitation of NaCl–NaCl contacts could generate tensile stresses and weaken the tablet matrix . At 5%, w/w NaCl, the amount of NaCl may not be sufficient to cause significant weakening of the tablet matrix during post-compaction storage.…”

Section: Discussionmentioning

confidence: 99%

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Understanding the Roles of Excipients in Moisture Management in Solid Dosage Forms

Veronica,

Heng,

Liew

2024

Mol. Pharmaceutics

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Excipients are ubiquitous in pharmaceutical products, and often, they can also play a critical role in maintaining product quality. For a product containing a moisture-sensitive drug, moisture can be deleterious to the product stability during storage. Therefore, using excipients that interact with moisture in situ can potentially alleviate product stability issues. In this study, the interactive behavior of starch with moisture was augmented by coprocessing maize starch with sodium chloride (NaCl) or magnesium nitrate hexahydrate [Mg(NO 3 ) 2 •6H 2 O] at different concentrations (5 and 10%, w/w). The effect of the formulation on drug stability was assessed through the degradation of acetylsalicylic acid, which was used as the model drug. The results showed that coprocessing of the starch with either NaCl or Mg(NO 3 ) 2 •6H 2 O impacted the number of water molecule binding sites on the starch and how the sorbed moisture was distributed. The coprocessed excipients also resulted in lower drug degradation and lesser changes in tablet tensile strength during postcompaction storage. However, corresponding tablet formulations containing physical mixtures of starch and salts did not yield promising outcomes. This study demonstrated the advantageous concomitant use of common excipients by coprocessing to synergistically mitigate the adverse effects of moisture and promote product stability when formulating a moisture-sensitive drug. In addition, the findings could help to improve the understanding of moisture−excipient interactions and allow for the judicious choice of excipients when designing formulations containing moisture-sensitive drugs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Understanding the Roles of Excipients in Moisture Management in Solid Dosage Forms

Veronica,

Heng,

Liew

2024

Mol. Pharmaceutics

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“…Namun demikian, pemanfaatan amilum masih memberikan hasil kerapuhan dan kekerasan yang buruk pada tablet, sedangkan persyaratan suatu sediaan tablet harus memiliki tingkat kerapuhan dan kekerasan yang baik (Nguyen dkk., 2013;Radojevic dan Zavaliangos, 2017). Untuk memperbaiki hal itu maka dapat dilakukan modifikasi fisika dengan pregelatinasi dan ko-proses terhadap amilum (Awaluddin dkk., 2017;…”

Section: Pendahuluanunclassified

Formulasi dan Evaluasi Tablet Kaptopril Menggunakan Amilum Umbi Talas dan HPMC yang Dimodifikasi Sebagai Pengisi dan Pengikat Metode Kempa Langsung

Kelana

Kusuma

Indrati

2018

eksakta

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Indonesia is a tropical country which has many potential plants as excipients, like starches and tubers. Amylum of taro tuber (Colocasia esculenta) has the potential to be developed into excipient but its use is limited. The purpose of this study was to optimize the formulation and to evaluate the characteristics of captopril tablets by using amylum of taro tuber and HPMC modified as filler and binder on direct compression method. Amylum of taro tuber was obtained by extraction process, then combined with HPMC by partial pregelatination and co-process method. Variation of the starch was divided into five formulation. The main test included friability test, hardness test, dissolution test, and assay. The data analysis was done by theoretical approach between the evaluation result and the literature to observe the result of the modification formulation. It indicated that the combination of equal amount of taro amylum and microcrystalline cellulose (MCC) PH 102 (50% : 50%) has the best result among others. Friability percentage was 0.17 ± 0.07%, disintegration time was 12.09 ± 0.52 minutes, assay was 97.88 ± 1.71% and dissolution test results was 90.65 ± 4.81%.Keywords: Tablet, Captopril, Co-Process, Partial Pregelatination ABSTRAK Indonesia adalah negara tropis yang memiliki banyak tumbuhan yang potensial dikembangkan sebagai bahan tambahan obat seperti pati dan umbi. Amilum dari umbi talas (Colocasia esculenta) berpotensi dikembangkan menjadi bahan tambahan obat tetapi peggunaannya masih terbatas. Penelitian ini bertujuan untuk membuat dan mengevaluasi sediaan tablet kaptopril menggunakan amilum umbi talas dan HPMC yang dimodifikasi sebagai pengisi dan pengikat pada metode kempa langsung. Amilum talas diperoleh melalui proses ekstraksi, kemudian dikombinasi dengan HPMC den gan metode pregelatinasi parsial dan ko-proses. Variasi penggunaan amilum dibedakan menjadi lima formulasi. Pengujian yang dilakukan meliputi evaluasi sifat alir granul sebelum kempa, dan serangkaian evaluasi tablet, yakni uji keragaman bobot, uji keragaman ukuran, uji kerapuhan, uji kekerasan, uji waku hancur, uji disolusi, dan penetapan kadar. Hasil evaluasi menunjukkan bahwa formulasi yang mengandung amilum talas pregelatinasi : mikrokristalin selulosa (MCC) PH 102 (50:50) memiliki hasil evaluasi sifat fisik tablet yang paling baik dilihat dari uji kerapuhan yaitu 0,17±0,07 %, waktu hancur 12,09±0,52 menit, penetapan kadar 97,88±1,71 % dan hasil uji disolusi 90,65±4,81 %.

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“…Such CPE processing attempted to gain the benefits of its constituent components, including the compactibility and good flow properties (Awaluddin et al, 2017;Kusuma et al, 2014;Radojevic dan Zavaliangos, 2017). MCC PH 101, lactose, and kollidon K30 were mixed and spray dryed to obtain CPE powder.…”

Section: Introductionmentioning

confidence: 99%

Flexibility of Custom Design over Simplex Lattice Design in Co-Processed Excipient Formulations

Kusuma

2018

STI

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Custom design is a modeling technique that puts forward customized formula in a pharmaceutical formula optimization. The components may be adjusted to the formula constraints. However, these designs sometimes do not accommodate all the components used. In addition, its effectiveness is not necessarily optimal when compared with standard designs such as simplex lattice design (SLD). This study used computerized variations of microcrystalline cellulose PH 101 (MCC PH 101), lactose, and Kollidon K30. Custom design and SLD were compared using the Design Expert software based on previous research data. Hardness and tapping index became test parameters to assess the design effectiveness. The obtained optimum formula was MCC PH 101 : lactose : Kollidon K30 each at 80% : 10% : 10% for SLD. Unlike this finding, the custom design resulted in the absence of lactose proportion in its optimum formula. The predicted custom design had better hardness and tapping index than those of SLD instead.

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On the Post-Compaction Evolution of Tensile Strength of Sodium Chloride-Starch Mixture Tablets

Cited by 10 publications

References 51 publications

Understanding the Roles of Excipients in Moisture Management in Solid Dosage Forms

Understanding the Roles of Excipients in Moisture Management in Solid Dosage Forms

Formulasi dan Evaluasi Tablet Kaptopril Menggunakan Amilum Umbi Talas dan HPMC yang Dimodifikasi Sebagai Pengisi dan Pengikat Metode Kempa Langsung

Flexibility of Custom Design over Simplex Lattice Design in Co-Processed Excipient Formulations

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