On the preliminary design of hyperthermia treatments based on infusion and heating of magnetic nanofluids

Michele, Federica Di; Pizzichelli, G.; Mazzolai, Barbara; Sinibaldi, Edoardo

doi:10.1016/j.mbs.2014.12.006

Cited by 20 publications

(7 citation statements)

References 51 publications

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“…Recently a research group led by Sinibaldi [44] provided a quantitative framework to demonstrate nanofluid infusion and the subsequent thermal activation of the infused nanoparticles for hyperthermia treatment. A simplified analytical technique was adopted to predict the nanoparticles concentration profile during the infusion process.…”

Section: Experimental/theoretical Modelling Studies Of Magnetic Nanopmentioning

confidence: 99%

A review on hyperthermia via nanoparticle-mediated therapy

et al. 2017

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Section: Experimental/theoretical Modelling Studies Of Magnetic Nanopmentioning

confidence: 99%

A review on hyperthermia via nanoparticle-mediated therapy

et al. 2017

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“…However, the preclinical representativeness of tumor invasion assays can be strengthened by using tumor spheroids models instead of single cells. Indeed, carrier transport in tumor tissue is affected by complex physical phenomena (including, e.g., interstitial flows, tissue heterogeneity, and carrier absorption/desorption dynamics) that, while posing modeling challenges [ 61 , 62 ], are being increasingly addressed through experimental microfluidic systems [ 63 ]. Thus, further in vitro investigations on advanced tumor models are needed to better assess the targeting efficacy of DOX_MagLipo, whence the potential for effective translation of our liposomal formulation to in vivo, clinically representative application scenarios.…”

Section: Discussionmentioning

confidence: 99%

Enhanced In Vitro Magnetic Cell Targeting of Doxorubicin-Loaded Magnetic Liposomes for Localized Cancer Therapy

et al. 2020

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The lack of efficient targeting strategies poses significant limitations on the effectiveness of chemotherapeutic treatments. This issue also affects drug-loaded nanocarriers, reducing nanoparticles cancer cell uptake. We report on the fabrication and in vitro characterization of doxorubicin-loaded magnetic liposomes for localized treatment of liver malignancies. Colloidal stability, superparamagnetic behavior and efficient drug loading of our formulation were demonstrated. The application of an external magnetic field guaranteed enhanced nanocarriers cell uptake under cell medium flow in correspondence of a specific area, as we reported through in vitro investigation. A numerical model was used to validate experimental data of magnetic targeting, proving the possibility of accurately describing the targeting strategy and predict liposomes accumulation under different environmental conditions. Finally, in vitro studies on HepG2 cancer cells confirmed the cytotoxicity of drug-loaded magnetic liposomes, with cell viability reduction of about 50% and 80% after 24 h and 72 h of incubation, respectively. Conversely, plain nanocarriers showed no anti-proliferative effects, confirming the formulation safety. Overall, these results demonstrated significant targeting efficiency and anticancer activity of our nanocarriers and superparamagnetic nanoparticles entrapment could envision the theranostic potential of the formulation. The proposed magnetic targeting study could represent a valid tool for pre-clinical investigation regarding the effectiveness of magnetic drug targeting.

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“…A terapia de hipertermia pode ser empregada no tratamento de câncer, tornando-se especialmente útil em casos nos quais os tumores oferecem algum tipo de resistência à quimioterapia, sendo utilizada então para aumentar a eficácia do tratamento ao ser combinada com quimioterapia ou radioterapia [15] entre o núcleo das NPs e o ambiente, tormar as partículas hidrossolúveis, além de proteger e estabilizar o núcleo de ferro. O revestimento das MNPs foi feito durante a síntese.…”

Section: Síntese Da Magnetitaunclassified

Influência Do Tempo De Revestimento No Tamanho E Estabilidade De Nanoparticulas De Magnetita Para Tratamentos De Hipertermia Magnética

Paresque¹,

Oliveira²,

Castro³

2019

TMM

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Em tratamentos de hipertermia magnética, as etapas de produção e revestimento das nanopartículas magnéticas são de fundamental importância para sua funcionalidade e eficiência durante a dinâmica do tratamento. O método de coprecipitação vem sendo utilizado para sintetizar nanopartículas de magnetita (Fe 3 O 4), largamente utilizadas neste tratamento. As mesmas foram recobertas com uma camada polimérica de polietilenoglicol (PEG) visando prevenir a oxidação do núcleo, permitir sua dispersão em água, aumentar sua estabilidade coloidal, bem como evitar a aglomeração das nanopartículas. Foram realizadas cinco sínteses, cada uma delas com tempos da etapa de revestimento das nanopartículas de 10, 20, 30, 50 e 60 minutos, respectivamente. Foram avaliadas a influência do tempo de revestimento no tamanho das partículas utilizando Nanoparticle Traking Analysis (NTA) e a estabilidade do revestimento por TGA/DSC. As nanopartículas revestidas apresentaram diâmetros médios na faixa de 31 a 40 nm. Analises no TGA/DSC permitiram observar a presença de uma camada adsorvida na superfície do núcleo magnético, bem como a eficácia do polietilenoglicol na proteção do núcleo de magnetita.

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On the preliminary design of hyperthermia treatments based on infusion and heating of magnetic nanofluids

Cited by 20 publications

References 51 publications

A review on hyperthermia via nanoparticle-mediated therapy

A review on hyperthermia via nanoparticle-mediated therapy

Enhanced In Vitro Magnetic Cell Targeting of Doxorubicin-Loaded Magnetic Liposomes for Localized Cancer Therapy

Influência Do Tempo De Revestimento No Tamanho E Estabilidade De Nanoparticulas De Magnetita Para Tratamentos De Hipertermia Magnética

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