On the Protective Effect of 2,4 Dinitrophenol

Vácek, A; Rotkovská, D

doi:10.1080/09553006414550301

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…PG is a compound that requires oxygen for metabolism, and increased 0 2 consumption can reduce the oxygen tension within cells, as we have observed after DNP administration ( 11). PAPP in PG did used as a vehicle; however, when PG or PAPP in PG was injected, only slight elevation of oxygen tension was observed.…”

Section: Drop In Extinction Of First Tube Drop In Extinction Of 2nd Tmentioning

confidence: 67%

Relationship Between Oxygen Tension in Tissues and the Protective Action of Para-Aminopropiophenone and of Propylene Glycol

Vácek

Sugahara

1967

Experimental Biology and Medicine

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Section: Drop In Extinction Of First Tube Drop In Extinction Of 2nd Tmentioning

confidence: 67%

Relationship Between Oxygen Tension in Tissues and the Protective Action of Para-Aminopropiophenone and of Propylene Glycol

Vácek

Sugahara

1967

Experimental Biology and Medicine

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“…Extensive uncoupling of oxidative phosphorylation with sharp oxygen consumption in cells induces to the development of acute cellular hypoxia that is key factor for an implementation of high radioprotective effect. This fact was confirmed by the administration of uncoupler of oxidative phosphorylation 2,4-dinitriphenol when it was detected 100% protective effect (Praslicka et al 1962 ; Vacek and Rotkovska 1964 ).…”

Section: Reviewmentioning

confidence: 84%

Comments on the mechanisms of action of radiation protective agents: basis components and their polyvalence

Vasin

2014

SpringerPlus

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PurposeThese comments suggest a division of radiation protective agents on the grounds of their mechanism of action that increase the radio resistance of an organism.ConclusionGiven below is the division of radiation protective agents on the basis of their mechanism of action into 3 groups: 1) Radiation protective agents, with the implementation of radiation protective action taking place at the cellular level in the course of rapidly proceeding radiation-chemical reactions. At the same time, when the ionizing radiation energy is absorbed, these agents partially neutralize the “oxygen effect” as a radiobiological phenomenon, especially in the radiolysis of DNA; 2) Radiation protective agents that exert their effect at the system level by accelerating the post-radiation recovery of radiosensitive tissues through activation of a number of pro-inflammatory signaling pathways and an increase in the secretion of hematopoietic growth factors, including their use as mitigators in the early period after irradiation prior to the clinical development of acute radiation syndrome (ARS). 3) Radiomodulators including drugs and nutritional supplements that can elevate the resistance of the organism to adverse environmental factors, including exposure to ionization by means of modulating the gene expression through a hormetic effect of small doses of stressors and a “substrate” maintenance of adaptive changes, resulting in an increased antioxidant protection of the organism. Radiation protective agents having polyvalence in implementation of their action may simultaneously induce radioprotective effect by various routes with a prevalence of basis mechanisms of the action.

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Depression of the isolated guinea pig atrium by β-mercaptoethylamine, β-adrenergic blocking agents, and metabolic inhibitors

Demaree

Heiffer

Jacobus

et al. 1966

Toxicology and Applied Pharmacology

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On the Protective Effect of 2,4 Dinitrophenol

Cited by 5 publications

References 6 publications

Relationship Between Oxygen Tension in Tissues and the Protective Action of Para-Aminopropiophenone and of Propylene Glycol

Relationship Between Oxygen Tension in Tissues and the Protective Action of Para-Aminopropiophenone and of Propylene Glycol

Comments on the mechanisms of action of radiation protective agents: basis components and their polyvalence

Depression of the isolated guinea pig atrium by β-mercaptoethylamine, β-adrenergic blocking agents, and metabolic inhibitors

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