On the protonation of glycocholate and glycodeoxycholate ions

Bottari, Emilio; Festa, Maria Rosa

doi:10.3184/095422999782775654

Cited by 3 publications

(4 citation statements)

References 15 publications

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“…NaTC 14 and NaGC 16 structural studies showed that dimers and octamers can be the building blocks of their micellar aggregates. Studies of NaTC aqueous solution composition confirmed the structural model. , Moreover, the solubility of glycocholic acid (HGC) and the protonation constant of glycocholate ion (GC - ) were determined …”

Section: Introductionmentioning

confidence: 69%

“…However, the reagent material balances are the basis for the subsequent elaboration. They, by taking into account the mass action law, can be written as follows: In (6) and (7), k 1 is the glycocholate protonation constant previously determined together with the solubility of HGC in the same experimental conditions . In Table , k 1 and solubility values for all the studied W are reported.…”

Section: Resultsmentioning

confidence: 99%

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Composition of Sodium Glycocholate Micellar Solutions

2002

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Composition and existence range of aggregates formed by sodium glycocholate in aqueous solutions were studied. Electromotive force measurements provided hydrogen, sodium, and glycocholate ion free concentrations. Lead(II) glycocholate solubility measurements yielded the free concentration of glycocholate ions, as well. Experimental data obtained at 25 °C and at three different concentrations of N(CH3)4Cl, used as a constant ionic medium, can be explained by assuming the presence of aggregates with different compositions, depending on reagent and ionic medium concentrations. The distribution of the species found at the same concentration of ionic medium and close to neutrality remains constant. As expected, the size of the aggregates increases by increasing ionic medium and reagent concentrations. A dimer is the prevailing species at low concentrations, and all of the found species have even anion aggregation numbers. In solutions with the highest concentration and ionic strength, aggregate multiples of eight are present at a high percentage. These results agree with structural investigations that proposed as building blocks of sodium glycocholate micellar aggregates a dimer and an octamer. A strong analogy with the composition of taurococholate aqueous solutions is observed. The comparison with deoxycholate, glycodeoxycholate, and taurodeoxycholate shows wide differences.

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Section: Introductionmentioning

confidence: 69%

Section: Resultsmentioning

confidence: 99%

Composition of Sodium Glycocholate Micellar Solutions

2002

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“…27 The elaboration of the experimental data was carried out in two different steps. At first the graphic method proposed by Sillèn 28 was applied and successively all the points without preliminary hypothesis were introduced in a PC program to have also the refined constants of the aggregates.…”

Section: Preliminary Informationmentioning

confidence: 99%

Composition of Aqueous Solutions Containing Sodium Glycocholate and Glycodeoxycholate

Bottari

Festa

2005

Annali di Chimica

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Composition and existence range of aggregates formed by sodium glycocholate and glycodeoxycholate contemporary present in aqueous micellar and premicellar solutions were investigated. Solubility measurements of lead (II) glycocholate and glycodeoxycholate give analytical concentration of lead (II) and glycocholate and glycodeoxycholate, respectively. Electromotive force measurements provide the free concentration of hydrogen, sodium and lead (II) ions. Experimental data obtained at 25 degrees C and at three different concentrations of N(CH3)4Cl, used as a constant ionic medium, can be explained by assuming the presence of aggregates of different composition depending on the reagent and ionic medium concentrations. Next to two species containing only glycocholate or glycodeoxycholate, the presence of aggregates formed with the contemporary participation of both bile anions in different ratios was assumed. Species with the hydrogen ion participation are not present in appreciable quantity in the investigated concentration range. As expected, the size of aggregates increases by increasing reagent and ionic medium concentration. Most of the species can be explained with a "core + link" mechanism, where all the glycocholate aggregation numbers are even, while those of glycodeoxycholate are always multiple of three. Analogy and difference with aggregates formed by the two bile anions separately are discussed.

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“…The constant k' was determined as previously described 13 for both acids and concentrations of ionic medium.…”

Section: Cholic Acid (Hcol) and Glycocholic Acid (Hgc)mentioning

confidence: 99%

The Influence of the Ionic Medium on the Behaviour of Sodium Glycocholate and Cholate Aqueous Solutions

2005

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In the framework of research on the sodium bile salts, solutions of sodium cholate and glycocholate had been studied only at three ionic medium concentrations. In this paper, experiments in two other concentrations of ionic medium are carried out both to verify the behaviour dependence on the ionic medium and to apply the results of this paper to a future investigation on solutions containing contemporary sodium cholate and glycocholate. To this aim, solubility, protonation constants, lead (II) salts solubility products at 25 degrees C and in 0.300 and 0.750 mol dm(-3) N(CH3)4Cl were determined. The formed species in solutions containing lead (II) together with the selected bile salts and the behaviour of the sodium salts in micellar and premicellar solutions were investigated, too. The obtained results were compared with those obtained at the other ionic medium concentrations.

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On the protonation of glycocholate and glycodeoxycholate ions

Cited by 3 publications

References 15 publications

Composition of Sodium Glycocholate Micellar Solutions

Composition of Sodium Glycocholate Micellar Solutions

Composition of Aqueous Solutions Containing Sodium Glycocholate and Glycodeoxycholate

The Influence of the Ionic Medium on the Behaviour of Sodium Glycocholate and Cholate Aqueous Solutions

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