2007
DOI: 10.1016/j.asr.2006.11.034
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On the quality of mutations in mammalian cells induced by high LET radiations

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Cited by 4 publications
(10 citation statements)
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“…For example, Suzuki et al observed decrease in the number of partial deletions with increasing LET of C-ion beams (39-230 keV/μm) in the human embryonic fibroblast-like cells [29], but in the case of Ne-ion beams (63-335 keV/μm), the number of mutants with partial deletions stayed practically the same [21]. Our findings coincide with the observations of Jostes et al (X-rays and alpha particles of 222 Rn and its decay products) [30], Bao et al (same as Jostes et al) [26], or Baumstark-Khan et al [8] who, as one of the few, actually studied the effects of accelerated heavy ions instead of alpha particles. Baumstark-Khan et al observed increase in the number of PD with LET up to 250-300 keV/μm of oxygen ions followed by decrease with even higher LET.…”
Section: Discussionsupporting
confidence: 90%
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“…For example, Suzuki et al observed decrease in the number of partial deletions with increasing LET of C-ion beams (39-230 keV/μm) in the human embryonic fibroblast-like cells [29], but in the case of Ne-ion beams (63-335 keV/μm), the number of mutants with partial deletions stayed practically the same [21]. Our findings coincide with the observations of Jostes et al (X-rays and alpha particles of 222 Rn and its decay products) [30], Bao et al (same as Jostes et al) [26], or Baumstark-Khan et al [8] who, as one of the few, actually studied the effects of accelerated heavy ions instead of alpha particles. Baumstark-Khan et al observed increase in the number of PD with LET up to 250-300 keV/μm of oxygen ions followed by decrease with even higher LET.…”
Section: Discussionsupporting
confidence: 90%
“…The published data seem to have a high degree of variety; nevertheless, some general conclusions can be drawn: radiation with higher LET (mainly alpha particles tested) usually caused more total deletions and lower number of partial deletions [19] or samples with no deletions [8,20] in comparison to low LET radiation (gamma or X ray). However, studies showing the same or very similar levels of total deletions after irradiation with alpha particles or gamma radiation can be found as well [24,26,30]-a minority of authors even observed lower numbers of total deletions after irradiation with higher LET radiation [31].…”
Section: Introductionmentioning
confidence: 98%
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