On the quantification of the dissolved hydroxyl radicals in the plasma-liquid system using the molecular probe method

Ma, Yupengxue; Gong, Xinning; He, Bangbang; Li, Xiaofei; Cao, Dianyu; Li, Junshuai; Xiong, Qing; Chen, Qiang; Chen, Bing Hui; Liu, Qing

doi:10.1088/1361-6463/aab379

Cited by 17 publications

(19 citation statements)

References 51 publications

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“…Interestingly, in combination with the reference‐fluorescence emission of the nanoparticle itself, enabled the ratiometric sensing of OH • . Recently, nanoparticles that achieved the quantification of dissolved OH • in a plasma–liquid system was reported …”

Section: Fluorescent Probes For the Detection Of Ros‐related Diseasesmentioning

confidence: 99%

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

et al. 2019

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Reactive oxygen species (ROS) consist of a diverse range of oxidative small molecular ions and free radicals that are produced throughout the body during certain biological processes. Due to their high reactivity, these molecules result in the damage of tissues and cells. Therefore, ROS have been implicated in an array of diseases including cancer, inflammation, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Owing to the simplicity, sensitivity, and selectivity of fluorescence‐based strategies, many small‐molecular sensors or imaging agents have been developed to sense and visualize ROS both in vitro and in vivo. Likewise, activatable drug delivery and prodrug systems that can be triggered by ROS for disease theranostics (diagnostic and therapeutic combined) have been developed. Herein, recently developed fluorescence‐based sensing and imaging agents for the detection of ROS both intracellularly and in vivo are summarized. In addition, drug delivery, which require activation by ROS to achieve disease theranostics is also discussed.

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Section: Fluorescent Probes For the Detection Of Ros‐related Diseasesmentioning

confidence: 99%

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

et al. 2019

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“…The products of the reaction, formaldehyde (HCHO) and methanesulfinic acid, are analyzed, e.g., by HPLC (HCHO is first subjected to derivatization with 2,4-dinitrophenyl hydrazine). 57,110,111 However, the results may not be quantitative due to the possible degradation of the analyzed product: HCHO is over-oxidized to CO 2 by • OH in the presence of O 2 . 111 Thus, chromatography and/or mass spectrometry present valuable analytical options for the analysis of plasma-produced RONS in liquids, albeit not always quantitatively straightforward.…”

Section: Application Modementioning

confidence: 99%

“…57,110,111 However, the results may not be quantitative due to the possible degradation of the analyzed product: HCHO is over-oxidized to CO 2 by • OH in the presence of O 2 . 111 Thus, chromatography and/or mass spectrometry present valuable analytical options for the analysis of plasma-produced RONS in liquids, albeit not always quantitatively straightforward. Chemical modification of substrates may be nonselective and require complex optimization of analytical conditions together with careful kinetic considerations.…”

Section: Application Modementioning

confidence: 99%

Analysis of Short-Lived Reactive Species in Plasma–Air–Water Systems: The Dos and the Do Nots

2018

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This Feature addresses the analysis of the reactive species generated by nonthermal atmospheric pressure plasmas, which are widely employed in industrial and biomedical research, as well as first clinical applications. We summarize the progress in detection of plasma-generated short-lived reactive oxygen and nitrogen species in aqueous solutions, discuss the potential and limitations of various analytical methods in plasma−liquid systems, and provide an outlook on the possible future research goals in development of short-lived reactive species analysis methods for a general nonspecialist audience.

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“…Other alternatives include different chemical probes, such as, e.g., dimethylsulphoxide, followed by quantification of the formed formaldehyde HCHO or methanesulfinic acid [35,40] (Scheme 2). However, other reactions leading to both production and degradation of HCHO can occur in a plasma-liquid system, as was shown by Ma et al [40]. The kinetics of these complex chemical processes needs to be considered for quantitative assessment of the hydroxyl radical in liquids.…”

Section: Detection Of Plasma-generated Rons In Liquids 21 Hydroxyl Amentioning

confidence: 99%

Chemical Detection of Short-Lived Species Induced in Aqueous Media by Atmospheric Pressure Plasma

Gorbanev¹,

Bogaerts²

2019

Atmospheric Pressure Plasma - From Diagnostics to Applications

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Non-thermal atmospheric pressure plasmas are widely used in biomedical research and clinical applications. Such plasmas generate a variety of reactive oxygen and nitrogen species upon interaction with ambient surroundings. These species further interact with a biological substrate and are responsible for the biomedical effects of plasma. Liquid water is an essential part of any biological systems. Some of the most reactive species induced by plasma in aqueous media are radicals and atoms. Hence, the presence of certain chemical components in a plasma 'cocktail' presents an important task for both understanding and further development of plasma systems with specific purposes. In this chapter, we discuss various methods of detection of the plasma-generated short-lived reactive species. We dissert various plasma-induced radicals and atoms (•OH, O 2 • − /•OOH, •NO, O), together with non-radical short-lived species (− OONO, O 3 , 1 O 2). Electron paramagnetic resonance (EPR) is the most direct method of radical detection in water-based media. Special attention is paid to the limitations of the detection methods, with an emphasis on spin trapping used in EPR analysis.

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On the quantification of the dissolved hydroxyl radicals in the plasma-liquid system using the molecular probe method

Cited by 17 publications

References 51 publications

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

Analysis of Short-Lived Reactive Species in Plasma–Air–Water Systems: The Dos and the Do Nots

Chemical Detection of Short-Lived Species Induced in Aqueous Media by Atmospheric Pressure Plasma

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