On THE QUENCHING OF SINGLET OXYGEN BY Α‐TOCOPHEROL

Fahrenholtz, Susan R.; Doleiden, F. H.; Trozzolo, A. M.; Lamola, Angelo A.

doi:10.1111/j.1751-1097.1974.tb06610.x

Cited by 193 publications

(69 citation statements)

References 24 publications

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“…Alpha tocopherol has the highest biological activity of the various vitamin E derivatives (100) and the greatest free radical scavenging ability (68). Vitamin E acts directly on a number of oxygen-derived radicals, and it quenches highly reactive singlet oxygen (19). It also spares selenium and protects beta carotene from destruction in the body.…”

Section: Mode Of Action Of Nutritional Antioxidantsmentioning

confidence: 99%

Free Radicals, Exercise, and Antioxidant Supplementation

Kanter¹

1994

International Journal of Sport Nutrition

168

112

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Free radicals have been implicated in the development of diverse diseases such as cancer, diabetes, and cataracts, and recent epidemic-logical data suggest an inverse relationship between antioxidant intake and cardiovascular disease risk. Data also suggest that antioxidants may delay aging, Research has indicated that free radical production and subsequent lipid peroxidation are normal sequelae to the rise in oxygen consumption with exercise. Consequently, antioxidant supplementation may detoxify the peroxides produced during exercise and diminish muscle damage and soreness. Vitamin E, beta carotene, and vitamin C have shown promise as protective antioxidants. Other ingestible products with antioxidant properties include selenium and coenzyme. The role (if any) that free radicals play in the development of exercise-induced tissue damage, or the protective role that antioxidants may play, remains to be elucidated. Current methods used to assess exercise-induced lipid peroxidation are not extremely specific or sensitive; research that utilizes more sophisticated methodologies should help to answer many questions regarding dietary antioxidants.

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Section: Mode Of Action Of Nutritional Antioxidantsmentioning

confidence: 99%

Free Radicals, Exercise, and Antioxidant Supplementation

Kanter¹

1994

International Journal of Sport Nutrition

168

112

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“…and hydroxyl radical (·OH) (Burton et al, 1985), as well as with the superoxide radical (O 2 · − ) (Fukuzowa and Gebicki, 1983;Ozawa et al, 1983). Tocopherol can also react directly with singlet oxygen (Fahrenholtz et al, 1974;Littarru et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

Effects of Intraperitoneally Administered Lipoic Acid, Vitamin E, and Linalool on the Level of Total Lipid and Fatty Acids in Guinea Pig Brain with Oxidative Stress Induced by H₂O₂

Çelik¹,

Özkaya²

2002

BMB Reports

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The aim of our study was to investigate the protective effects of intraperitoneally-administrated vitamin E, dlalpha lipoic acid, and linalool on the level of total lipid and fatty acid in guinea pig brains with oxidative stress that was +vitamin E groups. While the proportion of the total w3 (omega 3), w6 (omega 6), and PUFA were found to be lowest in the H 2 O 2 group, they were slightly increased (p<0.05) in the lipoic acid group when compared to the control and H 2 O 2 + lipoic acid groups. However, the level of ΣSFA in the H 2 O 2 group was highest; the level of ΣUSFA in same group was lowest. As the proportion of ΣUSFA and ΣPUFA were found to be highest in the linalool group, they were decreased in the H 2 O 2 group when compared to the control group. Our results show that linalool has antioxidant properties, much the same as vitamin E and lipoic acid, to prevent lipid peroxidation. Additionally, vitamin E, lipoic acid, and linalool could lead to therapeutic approaches for limiting damage from oxidation reaction in unsaturated fatty acids, as well as for complementing existing therapy for the treatment of complications of oxidative damage.

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“…doi:10.1016/S0531-5131(03)01690-X using SAMP1 and its control SAMR1. This algae has a fast and stable growth rate and is expected to be an efficient resource of functional food containing various nutrients including a fluorescent red pigment and h-carotene which has about 100-fold faster reaction constant in scavenging singlet-oxygen than a-tocopherol [1] in addition to various minerals accumulated from deep-sea water when the algae is cultivated with it.…”

Section: Introductionmentioning

confidence: 99%

Further classification of skin alkaloids from neotropical poison frogs (dendrobatidae), with a general survey of toxic/noxious substances in the amphibia

Daly

Myers

Whittaker

1987

Toxicon

393

273

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Abstract. We investigated the potential of red algae cultivated with deep-sea water (D) as dietary anti-oxidants to ameliorate the redox levels in the main organs and in bone metabolism using SAMP1 and its control SAMR1, in comparison with the same algae cultivated with surface seawater. Only the D group showed marked increases of glutathione (GSH) levels in the liver (R1, 134%) and brain (R1, 128% and P1, 126%) as well as activities of GSH non-dependent peroxidase in the liver (R1, 138%) and the brain (R1, 117% and P1, 112%) but not GSH-dependent peroxidase. The D diet also exhibited beneficial effects on bone metabolism; elevations of femoral calcium, phosphorus, hydroxyproline for collagen, hexosamine for polysaccharides, and suppression of urinary excretion of hydroxyproline as an index of increased bone resorption. A three-point bending test showed that the D diet increased the stiffness and the strength of the femur, which correlated with increases in femoral calcium and phosphorus contents. The results suggest that red algae of the Gracilaria sp. cultivated with deep-sea water has the potential to ameliorate degenerative diseases of aging. D

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On THE QUENCHING OF SINGLET OXYGEN BY Α‐TOCOPHEROL

Cited by 193 publications

References 24 publications

Free Radicals, Exercise, and Antioxidant Supplementation

Free Radicals, Exercise, and Antioxidant Supplementation

Effects of Intraperitoneally Administered Lipoic Acid, Vitamin E, and Linalool on the Level of Total Lipid and Fatty Acids in Guinea Pig Brain with Oxidative Stress Induced by H₂O₂

Further classification of skin alkaloids from neotropical poison frogs (dendrobatidae), with a general survey of toxic/noxious substances in the amphibia

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On THE QUENCHING OF SINGLET OXYGEN BY Α‐TOCOPHEROL

Cited by 193 publications

References 24 publications

Free Radicals, Exercise, and Antioxidant Supplementation

Free Radicals, Exercise, and Antioxidant Supplementation

Effects of Intraperitoneally Administered Lipoic Acid, Vitamin E, and Linalool on the Level of Total Lipid and Fatty Acids in Guinea Pig Brain with Oxidative Stress Induced by H2O2

Further classification of skin alkaloids from neotropical poison frogs (dendrobatidae), with a general survey of toxic/noxious substances in the amphibia

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Product

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Effects of Intraperitoneally Administered Lipoic Acid, Vitamin E, and Linalool on the Level of Total Lipid and Fatty Acids in Guinea Pig Brain with Oxidative Stress Induced by H₂O₂