On the question of the origin of macrophages in the retina and the vitreous following photocoagulation (autoradiographic investigations by means of 3H-thymidine)

Gloor, B.

doi:10.1007/bf00407092

Cited by 47 publications

(10 citation statements)

References 27 publications

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“…Investigators have observed macrophages of hematogenous origin in rabbit eyes under a number of different conditions such as after intravitreal injection of hemoglobin Burke and Smith, 1981) or latex particles (Burke and Foster, 19821, intraocular implants of plastic lenses (Uenoyama et al, 1988a,b,c) and following photocoagulation lesions of the eyeball (Gloor, 1974). In conjunction with the hypopigmentation of the pigmented retinal epithelium, choroid and iris found in Chediak-Higashi syndrome in animal models (cats, cattle, mink, mice), Collier et al (1984) observed macrophages containing phagocytized melanosomes.…”

Section: Introductionmentioning

confidence: 99%

Macrophage invasion and phagocytic activity during lens regeneration from the iris epithelium in newts

Reyer

1990

Am. J. Anat.

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Following removal of the lens through the cornea, early stages of lens regeneration from the dorsal iris of the adult newt, Notophthalmus viridescens, were studied using light and electron microscopic observations on sectioned, plastic-embedded irises. Specimens were fixed in Karnovsky's fixative every 2 days from 0 to 12 and 15 days after lentectomy. Infiltration of the iris epithelium by macrophages and their phagocytosis of melanosomes and small fragments of iris epithelial cells were observed. These macrophages were characterized by coarse nuclear chromatin, numerous mitochondria, free ribosomes, granular endoplasmic reticulum, Golgi complexes, vesicles, lysosomes, and phagosomes containing ingested melanosomes. Lamellipodia of varying length projected from their surface. Most of the cells lying on or close to the posterior surface of the iris could be identified as macrophages by these criteria. During this period, there was enlargement of the intercellular spaces within the iris epithelium. The iris epithelial cells near the margin of the pupil elongated, lost their melanin pigment and some associated cytoplasm, and acquired abundant free polyribosomes to form a lens vesicle of depigmented cells.

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Section: Introductionmentioning

confidence: 99%

Macrophage invasion and phagocytic activity during lens regeneration from the iris epithelium in newts

Reyer

1990

Am. J. Anat.

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“…Pigment epithelium degranulation and migration towards a stimulating agent (in flammatory reaction, foreign body, etc.) are well-known facts [Rentsch, 1973;Gloor, 1974;Mandelcorn et al. 1975;Tano et al, 1980].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Experimental Intraocular Proliferation with Intravitreous 5-Fluouracil

Kulnig¹,

Binder²,

Riss³

et al. 1984

Ophthalmologica

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5-Fluouracil, administered at concentrations of 1 and 5 mg to inhibit experimental intraocular proliferation produced by intravitreously implanted fibroblasts in rabbits, produced tissue alterations revealed by TEM. The degranulation and migration of pigment epithelial cells, the incipient degradation of axons and myelin sheets, the migration of glial cells and the prominent edema of the inner layers indicated a non-negligible damage to the retina, suggesting to abstain from its use in human eyes and to search for less neurotoxic drugs, possessing the same inhibitory effect on intraocular proliferation.

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“…Others have investigated macrophage flux through injured or dis eased retinas [6,9,13,19], but the dynamics of intraretinal macrophage movement have not been studied in eyes subjected only to intravitreal injection. In studies of experimental hemorrhage, vitreal injection of blood components stimulated increased numbers of retinal macrophages [3,14]; the immature proliferative cells were probably passing through the retina in the vitread direction [3].…”

Section: Introductionmentioning

confidence: 99%

“…Invasion of the vitreous by macrophages follows retinal injury [6,9,13,19] and the intravitreal injection of foreign substances [3,7,11,14]. The blood-derived macrophages [13,14] enter the vitreous from the cili ary body, optic nerve and retinal and choroidal vessels [2,5,6,9,19].…”

Section: Introductionmentioning

confidence: 99%

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Ultrastructural Demonstration of Transretinal Migration by Vitreal Macrophages Marked with Latex Particles

Burke¹,

Foster²

1982

Ophthalmic Res

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The injection of 1.1-μm latex particles into the rabbit vitreous elicits an intravitral invasion of macrophages. The particle-filled macrophages are initially restricted to the vitreous, are later found at the vitreoretinal interface, and by 6 weeks are distributed throughout the inner layers of the retina. The phagocytes appear to lyse in the outer retinal layers, and the released particles are found between and within the cells of the photoreceptor region. The observations indicate that latex-marked macrophages from the vitreous can penetrate and migrate within the retina.

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On the question of the origin of macrophages in the retina and the vitreous following photocoagulation (autoradiographic investigations by means of 3H-thymidine)

Cited by 47 publications

References 27 publications

Macrophage invasion and phagocytic activity during lens regeneration from the iris epithelium in newts

Macrophage invasion and phagocytic activity during lens regeneration from the iris epithelium in newts

Inhibition of Experimental Intraocular Proliferation with Intravitreous 5-Fluouracil

Ultrastructural Demonstration of Transretinal Migration by Vitreal Macrophages Marked with Latex Particles

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