On the radiosensitivity of man in space

Esposito, Rosario; Durante, Marco; Gialanella, G.; Grossi, G. F.; Pugliese, M.; Scampoli, P.; Jones, T.D.

doi:10.1016/s0273-1177(01)00005-9

Cited by 7 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results from STS‐80 and STS‐95 have shown a time‐ and microgravity‐dependent increase in lymphocyte apoptosis and release of the cell death factor Fas/APO‐1 99 . There seems to be a decrease on the rates of cellular repopulation of stem and stromal cells as a function of time 100,101 . The number of eosinophils and lymphocytes and the lymphocyte response to mitogens were decreased in astronauts postflight compared to preflight, but the number of neutrophils was increased 102…”

Section: Physiological Changes During Space Flightmentioning

confidence: 99%

“…99 There seems to be a decrease on the rates of cellular repopulation of stem and stromal cells as a function of time. 100,101 The number of eosinophils and lymphocytes and the lymphocyte response to mitogens were decreased in astronauts postflight compared to preflight, but the number of neutrophils was increased. 102 Modifications in cell cycle may explain the decrease in the number of circulating lymphocytes observed in microgravity.…”

Section: Immunologic Functionmentioning

confidence: 99%

See 1 more Smart Citation

Physiological, Pharmacokinetic, and Pharmacodynamic Changes in Space

Graebe

Schuck

Lensing

et al. 2004

The Journal of Clinical Pharma

View full text Add to dashboard Cite

Medications have been taken since the first Mercury flight in 1967 and, since then, have been used for several indications such as space motion sickness, sleeplessness, headache, nausea, vomiting, back pain, and congestion. As the duration of space missions get longer, it is even more likely that astronauts will encounter some of the acute illnesses that are frequently seen on Earth. Microgravity environment induces several physiological changes in the human body. These changes include cardiovascular degeneration, bone decalcification, decreased plasma volume, blood flow, lymphocyte and eosinophil levels, altered hormonal and electrolyte levels, muscle atrophy, decreased blood cell mass, increased immunoglobulin A and M levels, and a decrease in the amount of microsomal P-450 and the activity of some of its dependent enzymes. These changes may be expected to have severe implications on the pharmacokinetic and pharmacodynamic properties of drug substances.

show abstract

Section: Physiological Changes During Space Flightmentioning

confidence: 99%

Section: Immunologic Functionmentioning

confidence: 99%