On the recovery of the electroretinogram after removal of intravitreal zinc particles

Schmidt, Jan Peter; Nies, C.; Mansfeld-Nies, Regina

doi:10.1007/bf00143049

Cited by 13 publications

(5 citation statements)

References 24 publications

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“…The values of the a-wave came to 93% and 85% respectively, and those of the b-wave to 94% and 88% respectively. These values correspond to those observed in earlier experiments with 12 rats implanted with glass filaments [6]. On the 49th day the a-waves and the b-waves in the group of smaller glass filaments (0.3 mm 2) had fully recovered, whereas in the group with larger glass filaments the b-waves measured 91% of control.…”

Section: Intact Fellow Eyessupporting

confidence: 68%

“…The course of metal intoxication at different stages or periods had already been demonstrated in earlier experiments with intravitreal iron and lead particles [6,7,9]. In the present investigations with iron wires it became apparent that the speed of functional deterioration increased in the last three months of the 360 observation days, representing something approaching a fourth period in the course of the metal intoxication.…”

Section: Discussionsupporting

confidence: 57%

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Surface area sizes of intravitreal iron wires: Their effects on the electroretinograms of rats

Schmidt

Max

1987

Doc Ophthalmol

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(i) The a- and b-wave amplitudes decreased rapidly within one day after iron wire implantation. During the following week the amplitudes recovered to some extent. In the course of the next few months the a- and b-wave amplitudes of the eyes implanted with the largest iron wires (1.2 mm2) decreased steadily to about 20% by the end of the observation time, whereas in the groups containing smaller iron wires the electroretinographic changes were limited. (ii) Implantation of equally-sized glass splinters reduced the a- and b-wave amplitudes to 65-75% in comparison to the intact fellow eye. Fast recovery of both potentials to 83-93% followed within two weeks. The mean values of the a-wave amplitudes reached nearly 100%, those of the b-wave 90-95% in the next month.

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Section: Intact Fellow Eyessupporting

confidence: 68%

Section: Discussionsupporting

confidence: 57%

Surface area sizes of intravitreal iron wires: Their effects on the electroretinograms of rats

Schmidt

Max

1987

Doc Ophthalmol

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“…Earlier experiments with inert glass filaments (1.3 mm 2) produced a decrease of the a-and b-wave amplitudes to 74% and 76% respectively compared with the intact eye one day after particle implantation (Schmidt and Wasserschaff, 1983); this finding represented the mechanical component of the total damage. Within 10 days a recovery of 90% and 87% respectively occurred.…”

Section: Discussionmentioning

confidence: 99%

“…When copper-containing particles have entered the vitreous cavity, the mechanical damage is variable and frequently extensive. Animal experiments have been performed with glass particles to determine the mechanical factor caused by invasion and extraction of the foreign bodies (Schmidt and Wasserschaff, 1983).…”

Section: Introductionmentioning

confidence: 99%

On the recovery of the electroretinogram after removal of intravitreal copper particles

1987

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This report details the influence of the time lapse and surface area size of intravitreal copper foreign bodies on the electroretinogram (ERG) and the recovery of the potentials after removal of the particles. Pure copper wires were implanted temporarily into the vitreous body of rat eyes in the area of the ora serrata and the values of the ERG were compared with those of the intact fellow eyes. In three different procedures with groups of 12 animals each the following results were obtained: (1) The metal toxicity of small copper particles (0.3 mm2) remaining one day in the vitreous body reduced the amplitudes of the a1-, a2-, and b-wave only 10% by the end of the observation time of 260 days, (2) The loss of ERG amplitudes increased to about 25% under the influence of larger copper particles (1.3 mm2; time lapse one day); and (3) Copper particles with an active surface of 1.3 mm2 remaining two days in the vitreous body caused a permanent loss of about 50%.

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“…Chalcosis is an eye disease associated with the presence of copper particles. The intra‐ocular copper particles can produce a 50% loss of permanent retinal cell function in 2 days (Schmidt et al 1987). Although the pathogenesis of chalcosis remains unclear, it is generally believed that it is due to free radicals attack.…”

mentioning

confidence: 99%

N‐acetyl‐serotonin reduces copper (I) ion‐induced lipid peroxidation in bovine retinal homogenates

Siu

Cheung

et al. 2001

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: Chalcosis is an ocular condition caused by penetration injury of copper or its alloy, which leads to extensive ocular inflammation. N-acetyl-serotonin has recently been identified as a potent antioxidant against free radical stress. In this study, we determined the efficacy of N-acetyl-serotonin against the copper (I)-induced retinal lipid peroxidation. Methods: Copper (I)-treated (100 mM) bovine retinal homogenates were incubated with 6 different concentrations (i.e. 0.00, 0.25, 0.50, 1.00, 2.00 and 4.00 mM) of N-acetyl-serotonin or vitamin E. The malondialdehyde level was measured as an index of lipid peroxidation. (p∞0.0001). The concentration to inhibit 50% of damage for N-acetyl-serotonin and vitamin E were found to be 1.54 mM and 0.45 mM, respectively. Conclusion: Although N-acetyl-serotonin is only 29% as effective as vitamin E in suppressing the copper (I)-induced lipid peroxidation, the present study supports a pharmacological potential of N-acetyl-serotonin combating free radical oxidative damages in the ocular tissues. Results: Copper (I) ions induced a significant dose-dependent increase in malondialdehyde (pΩ0.007). Co-incubation with N-acetyl-serotonin or vitamin E significantly suppressed the copper (I)-induced malondialdehyde production

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On the recovery of the electroretinogram after removal of intravitreal zinc particles

Cited by 13 publications

References 24 publications

Surface area sizes of intravitreal iron wires: Their effects on the electroretinograms of rats

Surface area sizes of intravitreal iron wires: Their effects on the electroretinograms of rats

On the recovery of the electroretinogram after removal of intravitreal copper particles

N‐acetyl‐serotonin reduces copper (I) ion‐induced lipid peroxidation in bovine retinal homogenates

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