Considering the problems of the internal and external disturbances of wind speed in the direct-drive wind energy conversion system based on a permanent magnet synchronous generator, a novel model predictive control based on the extended state observer method without the accurate mathematical system model is proposed in this paper. First, a model predictive control method is employed as the feedback controller, while the mathematical model of the control system can be adjusted online via the rolling optimization strategy. Second, an extended state observer is introduced to estimate the state variables and lumped disturbances, that is, the internal disturbances including nonlinear characteristic, multi-variety coupling effect, uncertainties of system parameters, and external disturbances including variations of wind speeds and uncertainties of the natural environment. Third, the effect of lumped disturbances can be attenuated by the estimated disturbance value via a feedforward channel. In addition, in order to achieve the real-time speed control performance of the permanent magnet synchronous generator, a speed sensorless algorithm based on a flux observer is proposed to solve the problem of unsuitability of mechanical speed sensor. Finally, the simulation results with several wind speed types show that the proposed sensorless model predictive control with the extended state observer strategy is an effective way to improve the performance of anti-disturbance and ability of tracking maximum wind energy of the wind power control system.