On the relation between haloperidol-induced alterations in DA release and DA metabolism in rat striatum

Moleman, P.; Bruinvels, J.; Valkenburg, C. F. M. Van

doi:10.1016/0024-3205(78)90041-3

Cited by 10 publications

(3 citation statements)

References 6 publications

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“…The effects of Hal on 3-MT accumulation in the ACC and of CLZ on 3-MT steady-state and accumulation in the ACC and PFC have not previously been described. Further, as demonstrated here for CLZ (compare the effects of CLZ in Tables 2 and 3) and previously reported by others Moleman et al, 1978;Zetterstrom et al, 1985;Nissbrandt et al, 1989), dopamine release and metabolism are clearly dissociable and hence may well represent different neuronal activities.…”

Section: Discussionsupporting

confidence: 84%

“…Differential effects of Hal and CLZ on DOPAC and HVA in the ACC and ST have previously been described (Anden & Stock, 1973;Wilk et al, 1975;Westerink & Korf, 1976). However, since Hal is known to inhibit the efflux of DOPAC and HVA from the brain (Moleman et al, 1978;Westerink et al, 1984), the elevations produced by Hal and CLZ may overestimate dopamine turnover or rate of utilization.…”

Section: Discussionmentioning

confidence: 94%

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Dopamine release and metabolism in the rat frontal cortex, nucleus accumbens, and striatum: a comparison of acute clozapine and haloperidol

Karoum¹,

Egan²

1992

British J Pharmacology

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1 The effects of the typical and typical neuroleptic agents clozapine (CLZ) (2.5-20mgkg 1, i.p.) and haloperidol (Hal) (0.05-1.Omgkg-1), were compared on dopamine release and metabolism in the rat prefrontal cortex (PFC), nucleus accumbens (ACC) and striatum (ST). Dopamine release was estimated by measuring the steady-state concentration of 3-methoxytyramine (3-MT) and the level of 3-MT 10min after pargyline (3-MT accumulation); dopamine metabolism was evaluated from the steady-state concentrations of its acidic metabolites. 2 Both drugs increased 3-MT accumulation in the PFC in a dose-dependent manner. In contrast to Hal, CLZ failed to increase 3-MT accumulation in the ACC or ST. The ST was the region most sensitive to Hal in terms of 3-MT accumulation and, by inference, dopamine release. 3 Both CLZ and Hal dose-dependently elevated the concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in all 3 brain regions studied. The ACC appears to be the region most sensitive to these drugs in terms of changes in the levels of HVA. 4 The result of the present investigations suggest measurements of 3-MT production in the 3 brain regions analysed might be a useful and simple pharmacological tool in the search for atypical neuroleptic drugs with a selectivity of action for the cortical systems.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 94%

Dopamine release and metabolism in the rat frontal cortex, nucleus accumbens, and striatum: a comparison of acute clozapine and haloperidol

Karoum¹,

Egan²

1992

British J Pharmacology

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“…It is possible that this apparent premature recovery of LCGU represents new receptor formaticn or the activation of regulatory mechanisms that tend to restore LCGU in affected regions. As a result of HAL administration, DA turnover increases in regions with dopaminergic terminals (Moleman et al, 1978;Meller et al, 1980;Ishikawa et al, 1982). In regions where postsynaptic metabolism has been depressed by DA receptor blockade, increased nerve terminal activity may restore measured glucose utilization.…”

Section: Preoptic Regionmentioning

confidence: 99%

Haloperidol and Cerebral Metabolism in the Conscious Rat: Relation to Pharmacokinetics

Pizzolato

Soncrant

Rapoport

1984

Journal of Neurochemistry

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The time course and distribution of alterations in cerebral metabolic activity after haloperidol administration were evaluated in relation to the pharmacokinetics of haloperidol and the topography of the dopaminergic system in the brain. Local cerebral glucose utilization was measured, using the 2-deoxyglucose technique, in awake rats after i.p. administration of the dopamine antagonist haloperidol (0.5 or 1 mg/kg). Haloperidol significantly reduced glucose utilization in 60% of 59 brain regions examined, but produced a large increase in the lateral habenula. The regional distribution of changes in glucose utilization was not closely related to the known anatomy of the brain dopaminergic system. The time course of the effect of haloperidol on cerebral metabolism was different for the two doses studied (0.5 and 1 mg/kg), and was not simply related to estimated brain concentrations of haloperidol. However, a linear relation between the metabolic effect and the time-integrated brain concentration was demonstrated. These results show that haloperidol has an effect on CNS metabolic activity that is more widespread than would be predicted from the topography of the dopaminergic system; this may be due to indirect propagation of the primary effects of haloperidol. The metabolic response to haloperidol depends on brain concentration and duration of exposure to the drug.

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Effect of des-tyr1-γ-endorphin and des-tyr1-α-endorphin on α-MPT-induced catecholamine disappearance in rat brain nuclei: A dose-response study

et al. 1982

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On the relation between haloperidol-induced alterations in DA release and DA metabolism in rat striatum

Cited by 10 publications

References 6 publications

Dopamine release and metabolism in the rat frontal cortex, nucleus accumbens, and striatum: a comparison of acute clozapine and haloperidol

Dopamine release and metabolism in the rat frontal cortex, nucleus accumbens, and striatum: a comparison of acute clozapine and haloperidol

Haloperidol and Cerebral Metabolism in the Conscious Rat: Relation to Pharmacokinetics

Effect of des-tyr1-γ-endorphin and des-tyr1-α-endorphin on α-MPT-induced catecholamine disappearance in rat brain nuclei: A dose-response study

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