The paper investigates the crack tip plasticity of laser stake-welded T-joints when the thickness of the face plate is varied. For thin joints, mixed-mode condition is dominant and the Minimum Plastic Zone Radius (MPZR) criterion is employed to estimate the crack initiation direction. Subsequently, the same first-order plastic zone size r y as defined by Irwin is kept equal for the selected load levels in the MPZR direction, and finite element (FE) analyses are carried out to investigate the stress gradient over r y comparing different thicknesses. The results allow us to explain why the fatigue slope m is different for thin and thick joints. Moreover, a new method is proposed that permits the number of cycles to failure of thin joints to be derived directly from the fatigue curve of thick joints, employing an effective J-integral. The results prove that the method is able to give an estimation of the number of cycles to failure for thin joints with acceptable error.