On the relationship between the frequency of two types of mutation and soft X-ray doses in drosophila

Matsudaira, Yoriaki; Ito, Takashi; Yamasaki, Terutoshi; Ishizaka, Shigeaki; Domon, M.

doi:10.1016/0027-5107(67)90009-7

Cited by 12 publications

(3 citation statements)

References 10 publications

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“…Recently, Munoz (1972) who performed the necessary statistical tests of fractional mutations of several loci published in the literature (Altenburg and Browning 1961; Sobels 1962;Matsudaira et al 1964Matsudaira et al , 1967Inagaki and Nakao 1966;Inagaki and Sobels 1972) showed that the evidence for the radiation-induction of fractional mutations at the y w sn loci (and other loci investigated by the Maxy technique) is at best meagre (none of the reported frequencies or rates was significantly higher than in the controls).…”

Section: Resultsmentioning

confidence: 99%

The prequency pattern of the dumpy mutations induced by X-rays in different stages of spermatogenesis of Drosophila.

Inagaki

Uchibori

Miyamoto

et al. 1977

The Japanese journal of genetics

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The dumpy locus (dp) located on the chromosome 2 at map position 13.0 is among the loci intensively studied in Dyosophila.Its usefulness and suitability for mutational studies derive from the findings that (i) it is a complex locus (or a closely linked group of distinct genes) with no less than 7 mutational sites Grace 1970), events at which are phenotypically detectable in certain combinations; (ii) the locus is much more sensitive than others to radiation as well as chemical mutagens Carlson and Oster 1962;Oster 1963;Jenkins 1967;Corwin 1968) and (iii) the induced events at this locus involve presumed point mutations as well as those associated with chromosome breakage, the latter resulting in extreme phenotype Carlson and Oster 1962).In an attempt to shed more light on the nature of radiation-induced dumpy mutations, a comparison was recently made by Inagaki et al. (1974) for the dose-frequency patterns between the different kinds of dumpy exceptions induced by X-rays in mature sperm. The experimental data revealed that (a) the yield of dumpy exceptions of the o and v types increases with exposure up to 3,000 R beyond which there is no further increase; (b) the frequency of the of and the lv exceptions tends to increase faster than linearly with no evidence for a decrease at 4,500 R; (c) the exposure-frequency relationship for the ov and olv exceptions does not depart from linearity; (d) the over-all frequencies of o, v, of and lv at the three exposure levels (1,500, 3,000 and 4,500 R) are also consistent with linear increase with exposures and (e) the frequency of fractional dumpy mutants appears to remain approximately the same irrespective of the exposure. Although the data cannot be considered as more than preliminary results on which a more thorough analysis will have to be based, the authors were inclined to suggest that the exposurefrequency relationships for the different kinds of dumpy mutations are different. Definite evidence apparently supporting the above observations has been recently obtained in a large-scale study of Fujikawa et al. (1975). More information about the spectrum of X-ray-induced dumpy mutations especially in various experimental conditions under which mutagensis by ionizing radiation in Dyosophila may be well subject to modification seemed to be needed before the picture of dose-response curves for the different kinds of dumpy exceptions could be properly interpreted.In view of this it

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Section: Resultsmentioning

confidence: 99%

The prequency pattern of the dumpy mutations induced by X-rays in different stages of spermatogenesis of Drosophila.

Inagaki

Uchibori

Miyamoto

et al. 1977

The Japanese journal of genetics

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“…However, it was reported that in Drosophila the frequency of fractional-body mutations were not linearly related to the dose (Matsudaira et al 1964(Matsudaira et al , 1967a, although the sum of fractional-and whole-mutation would be linear with the dose. Applying this to our case the effective mutation rate per generation (rp F + ~cw), which is to be used for the calculation of the mutational load, therefore, may not be linear with the dose, especially in the low dose region.…”

Section: Discussionmentioning

confidence: 98%

The Bearing of Fractional-Body Mutations on the Mutational Load

Matsudaira

Ito

1967

The Japanese journal of genetics

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“…The presumptive origin of fractional or mosaic mutations induced by radiation in Drosophila has often been discussed in terms of the strandedness of the DNA molecule (Muller et al 1961;Carlson and Southin 1962;Carlson and Oster 1962;Inagaki and Nakao 1966;Matsudaira et al 1967;Munoz 1972;Fujikawa et al 1975). In the course of our recent studies with the induction of the different kinds of dumpy mutations by X-rays in Drosophila males (Inagaki et al 1974;Inagaki et al 1977), it was found that the mosaic-looking individuals for losses of the BS or y+ marker from the marked Y-chromosome were recovered with an appreciable frequency.…”

mentioning

confidence: 99%

The frequency pattern of Y-chromosome loss mosaics induced by X-rays in Drosophila melanogaster.

Inagaki

Fujikawa

Miyamoto

et al. 1977

The Japanese journal of genetics

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On the relationship between the frequency of two types of mutation and soft X-ray doses in drosophila

Cited by 12 publications

References 10 publications

The prequency pattern of the dumpy mutations induced by X-rays in different stages of spermatogenesis of Drosophila.

The prequency pattern of the dumpy mutations induced by X-rays in different stages of spermatogenesis of Drosophila.

The Bearing of Fractional-Body Mutations on the Mutational Load

The frequency pattern of Y-chromosome loss mosaics induced by X-rays in Drosophila melanogaster.

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