On the Relevance of Glycolysis Process on Brain Gliomas

Kounelakis, M.G.; Zervakis, Michalis; Giakos, G. C.; Postma, G.J.; Buydens, L.M.C.; Kotsiakis, X.

doi:10.1109/titb.2012.2199128

Cited by 17 publications

(15 citation statements)

References 41 publications

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“…The glycolysis pathway is related to VaD, and genes involved in this pathway, such as GPI and GAPD, are significantly downregulated in the AD hippocampus [31,35]. In addition, PFKM, PGM1, ALDOA, and ALDOC are also downregulated in the entorhinal cortex of AD patients [32,36,37]. Our study showed that downregulated proteins were significantly enriched in the subpathways of the ‘glycolysis/gluconeogenesis' pathway.…”

Section: Discussionmentioning

confidence: 87%

Identification of Pivotal Markers in Vascular Dementia Based on Proteomics Data

Wang¹,

Zhao²,

Xu³

et al. 2015

Dement Geriatr Cogn Disord

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Objective: The aim of this study was to analyze protein expression profiles of vascular dementia (VaD) subjects for investigating the underlying therapeutic markers. Methods: Protein expression profile data were acquired from a quantitative clinical proteomic study, including 10 nondemented elderly controls and 10 age-matched VaD subjects. Differentially expressed proteins (DEPs) were identified between VaD subjects and controls, followed by function prediction using DAVID (Database for Annotation, Visualization, and Integrated Discovery). Then, a protein-protein interaction (PPI) network was constructed by comparing it with the STRING (Search Tool for the Retrieval of Interacting Genes) database, and the pathway crosstalk analysis was conducted based on overlapping PPI network and enriched pathways. Furthermore, the subpathway was screened and analyzed by the iSubpathwayMiner package in R. Results: A total of 144 DEPs were screened from VaD subjects and the controls. They were significantly enriched in many pathways. High-degree proteins were detected in the PPI network, such as ATP5B (ATP synthase subunit β). Furthermore, ‘metabolic pathways' and ‘Alzheimer's disease' were the significant pathways screened in the crosstalk analysis. At last, upregulated proteins were enriched in 2 subpathways of 1 pathway, while downregulated proteins were enriched in 162 subpathways of 36 pathways. Conclusion: By analyzing the differential expressions of proteins, the potential underlying therapeutic markers and mechanism of VaD might be elucidated.

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Section: Discussionmentioning

confidence: 87%

Identification of Pivotal Markers in Vascular Dementia Based on Proteomics Data

Wang¹,

Zhao²,

Xu³

et al. 2015

Dement Geriatr Cogn Disord

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“…Heightened expression of LDHB may contribute to tumor acidity, and growth (24) known to occur in parallel to activated RTK-PI3K-AKT-mTOR signaling (25) and is observed in various types of cancer including bladder (26) merkel cell carcinoma (27) lung cancer (28) glioma (29) or maxillary sinus squamous cell carcinoma, most reporting its association with poor survival rates (30). …”

Section: Discussionmentioning

confidence: 99%

Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival

2017

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“…Related study has shown that the combination of glycolytic genes, including PFKM , ALDOA , ALDOC , and PGM1 , participates in the glycolytic process. 29 6-Phosphofructokinase, muscle type is a regulatory protein coded by PFKM . It can transform fructose-6-phosphate into fructose-1,6-bisphosphate (F-1, 6-BP) in glycolysis, which is a key procedure in glycolysis.…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Profiles of Entorhinal Cortex in Alzheimer’s Disease

Ding

Yan

Gao

et al. 2014

Am J Alzheimers Dis Other Demen

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The incidence of Alzheimer's disease (AD) has been increasing in the recent years but the underlying mechanisms remain uncertain. This study aimed to analyze the differentially expressed genes (DEGs) in entorhinal cortex with AD and identify featured genes related to AD. Gene expression profile GSE5281 was downloaded from Gene Expression Omnibus, including 10 AD and 13 control samples. Differentially expressed genes were identified by Student t test including 119 upregulated and 591 downregulated DEGs. Then, we obtained 14 enrichment Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways among which 11 pathways were significantly enriched (adjusted P value < .05). The KEGG pathway network which was constructed by 14 KEGG pathways showed that 6-phosphofructokinase, muscle type, phosphoglucomutase 1, aldolase A, and adolase C had high degree. Glycometabolism pathways network which was constructed by 4 glycometabolism pathways showed that adenosine triphosphate (ATP) synthase, H+transporting, mitochondrial F1 complex ATP5B, ATP5C1, ATP5D, and ATP5G1 had high degree related to ATP metabolism. These findings suggested that these genes with high degree may be the underlying potential therapeutic targets for AD.

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On the Relevance of Glycolysis Process on Brain Gliomas

Cited by 17 publications

References 41 publications

Identification of Pivotal Markers in Vascular Dementia Based on Proteomics Data

Identification of Pivotal Markers in Vascular Dementia Based on Proteomics Data

Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival

Gene Expression Profiles of Entorhinal Cortex in Alzheimer’s Disease

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