On the Reliability of Systolic Time Intervals

Levi, Guido; Ratti, S. P.; Cardone, G; M, Basagni

doi:10.1159/000173498

Cited by 16 publications

(7 citation statements)

References 10 publications

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“…The best evidence so far comes from a study in 13 female undergraduate students (21) that showed a high correlation (0.82) between absolute PEP and heart period increases in response to sympathetic blockade. In further support, a significant inverse correlation between a subjects' absolute PEP and their plasma adrenaline level was found (48). Endurance athletes showed longer PEP than untrained controls (49).…”

Section: Discussionmentioning

confidence: 68%

Overcommitment to Work Is Associated With Changes in Cardiac Sympathetic Regulation

Vrijkotte

Doornen

Geus

2004

Psychosomatic Medicine

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Objective: Work stress is associated with an increased risk for cardiovascular disease (CVD). Exaggerated cardiovascular reactivity to work-related stressors or incomplete recovery after work is a proposed mechanism underlying this increase in risk. This study examined the effects of work stress on 24-hour profiles of the pre-ejection period (PEP), a measure of cardiac sympathetic activity, obtained from ambulatory measurement of the impedance cardiogram. Methods: A total of 67 male white-collar workers (age 47.1 Ϯ 5.2) underwent ambulatory monitoring on 2 workdays and 1 non-workday. Work stress was defined according to Siegrist's model as 1) a combination of high effort and low reward at work (high imbalance) or 2) an exhaustive work-related coping style (high overcommitment). Results: High overcommitment was associated with shorter absolute PEP levels during all periods on all 3 measurement days, reduced wake-to-sleep PEP differences and reduced PEP variability, as indexed by the SD. Conclusions: Overcommitment to work was associated with an increase in basal sympathetic drive and a reduction in the dynamic range of cardiac sympathetic regulation. Both findings are compatible with the hypothesis that overcommitment induces ␤-receptor down-regulation.

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Section: Discussionmentioning

confidence: 68%

Overcommitment to Work Is Associated With Changes in Cardiac Sympathetic Regulation

Vrijkotte

Doornen

Geus

2004

Psychosomatic Medicine

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“…It might be important to appreciate the day-to-day variation of the systolic time intervals even in patients with stable chronic heart disease. Levi et al (1982) demonstrated the sponraneous variation of systolic time intervals between observations and between days. They smssed the necessity of control groups mated with placebo to evaluate the pharmacological effects on the systolic time intervals.…”

Section: Discussionmentioning

confidence: 92%

Therapeutic effect of taurine in congestive heart failure: A double‐blind crossover trial

Azuma

Sawamura

Awata

et al. 1985

Clinical Cardiology

125

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“…The exercise values of STI were uncorrected for HR because these corrections would mask the inotropic effect. There was evidence against this practice (Levi et al 1982; Pigott et al 1971; Spodick and Quarry-Pigott 1973; Whitsett and Naughton 1971). …”

Section: Methodsmentioning

confidence: 99%

Cardiovascular and hormonal responses to static handgrip in young and older healthy men

et al. 2011

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The purpose of this study was to investigate the effect of age on cardiovascular changes and plasma concentrations of adrenomedullin (ADM), catecholamines, endothelin-1 (ET-1) and plasma renin activity (PRA) in healthy men. A total of 15 young (21 ± 0.3 years) and 15 older (64 ± 0.7 years) healthy men performed two 3-min bouts of static handgrip at 30% of maximal voluntary contraction, alternately with each hand without any break between the bouts. During exercise heart rate (HR), blood pressure (BP), stroke volume (SV) and pre-ejection period (PEP) and left ventricle ejection time (LVET) were measured. Blood samples were taken before exercise, at the end of both exercise bouts and in the fifth minute of the recovery period. The handgrip-induced increases in HR and cardiac output were significantly smaller in older than in young men (p < 0.01). SV decreased only in older men (p < 0.001). There were no differences between groups in BP increases. The baseline plasma ADM and catecholamines were higher in older man compared to young subjects. Handgrip caused increases in plasma ADM, ET-1 and PRA only in older men (p < 0.05). The increases in plasma ADM correlated positively with those of noradrenaline (NA), PRA, ET-1 and LVET and negatively with changes in total peripheral resistance (TPR), SV, PEP and PEP/LVET ratio. The increases in plasma ET-1 correlated positively with those of NA, PRA, TPR, mean BP and SV. These results revealed that ADM, ET-1 and angiotensin II can contribute to maintain vascular tone during static exercise in older but not in younger men.

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On the Reliability of Systolic Time Intervals

Cited by 16 publications

References 10 publications

Overcommitment to Work Is Associated With Changes in Cardiac Sympathetic Regulation

Overcommitment to Work Is Associated With Changes in Cardiac Sympathetic Regulation

Therapeutic effect of taurine in congestive heart failure: A double‐blind crossover trial

Cardiovascular and hormonal responses to static handgrip in young and older healthy men

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