On the Renal Site and Mode of Action of Glucocorticoid in Cirrhosis*

Jick, Hershel; Snyder, Julie; Finkelstein, Elliot; Cohen, Joseph L.; Moore, Edward W.; Morrison, Robert S.

doi:10.1172/jci104841

Cited by 14 publications

(10 citation statements)

References 10 publications

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“…If there were an increase in supply, it does not appear to have been mediated by a measurable rise in GFR. No significant alteration in GFR was evident in our studies or in those reported by others (19,29). In fact, hydrocortisone has been shown to produce a prompt rise in GFR only in glucocorticoid or salt-depleted subjects with reduced filtration rates (16)(17)(18)29).…”

Section: Resultssupporting

confidence: 58%

“…It is tempting to ascribe to hydrocortisone a similar direct hormonal effect on the rate of sodium transport at the ascending limb. Other investigators have suggested that methylprednisolone exerts such a direct hormonal action at this site (19). Although our data do not contradict this interpretation, the increase in ascending limb sodium transport may be explained entirely by an increased sodium supply to the loop of Henle.…”

Section: Resultscontrasting

confidence: 53%

“…The correction of this defect by *Submitted for publication January 9, 1964; accepted April 23, 1964. Supported by grant A-277 from the National Institute of Arthritis and Metabolic Diseases, Bethesda, Md hydrocortisone could not be attributed solely to the rise in glomerular filtration rate (GFR) frequently produced by this agent (16)(17)(18). In addition, others have recently reported that a glucocorticoid (methyl-prednisolone) increased solute free water reabsorption (TCH2O) in salt-depleted cirrhotics without altering GFR (19). Under hydropenic conditions, solute concentrations in the medullary interstitium and collecting duct fluid have been shown to be the same in any plane cut perpendicular to the axis of the medulla (20).…”

mentioning

confidence: 99%

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Renal Tubular Effects of Hydrocortisone and Aldosterone in Normal Hydropenic Man: Comment on Sites of Action *

Yunis¹,

Bercovitch²,

Stein³

et al. 1964

J. Clin. Invest.

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Section: Resultssupporting

confidence: 58%

Section: Resultscontrasting

confidence: 53%

mentioning

confidence: 99%

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Renal Tubular Effects of Hydrocortisone and Aldosterone in Normal Hydropenic Man: Comment on Sites of Action *

Yunis¹,

Bercovitch²,

Stein³

et al. 1964

J. Clin. Invest.

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“…Previous studies, in the absence of adrenal insufficiency, have suggested that glucocorticoid hormones increase glomerular filtration rate (1,2) and free water clearance (3,4) and may influence the tubular reabsorption of sodium (5,6).…”

mentioning

confidence: 99%

Effect of Methylprednisolone on Renal Function and the Zonal Distribution of Blood Flow in the Rat

deBermudez

Hayslett

1972

Circulation Research

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The effect of acute and chronic administration of methylprednisolone on renal function was studied in rats with clearance and micropuncture techniques. Although acute administration did not influence renal function, chronic administration for 4 days caused a marked increase in glomerular filtration rate and PAH clearance. The rise in the reabsurption of sodium under these conditions was associated with a disproportionate increase in filtration rate and renal blood flow in deep portions of the cortex. There was no evidence of altered fractional sodium reabsorption in the proximal segment of surface nephrons by micropuncture analysis or in the ascending limb by clearance studies during a water or a solute diuresis.KEY WORDS methylprednisolone sodium reabsorption micropuncture microspheres glomerular filtration PAH clearance proximal tubules• The effect of glucocorticoid hormones on renal function is of importance because of the striking alterations which occur in adrenal insufficiency and the widespread pharmacological use of these agents in patients with intact adrenal function. Previous studies, in the absence of adrenal insufficiency, have suggested that glucocorticoid hormones increase glomerular filtration rate (1, 2) and free water clearance (3, 4) and may influence the tubular reabsorption of sodium (5, 6).In the present study the action of methylprednisolone on sodium reabsorption by the renal tubule was examined in normal rats under conditions of acute and chronic administration by clearance and micropuncture techniques. In addition, since glucocorticoid From the

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“…Studies conducted 20 years ago had shown that corticosteroids increased glomerular filtration rate, free water clearance and potassium excretion while decreasing sodium excretion (3,8,28). However, an increase in renal plasma flow has also been reported by several authors (14,20).…”

Section: Discussionmentioning

confidence: 99%

Effect of High-Dose Prednisone on Renal Hemodynamics of Normal and Transplanted Dog Kidneys

Horpácsy¹,

Schuldt²,

Althaus³

et al. 1979

Eur Surg Res

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The effect of prednisone bolus therapy on renal hemodynamics was studied in normal, autotransplanted as well as homotransplanted dog kidneys. After intravenous administration of prednisone (8 and 16 mg/kg/min) the total blood flow decreased and vascular resistance increased significantly. This effect was more pronounced if the drug was directly injected into the arteria renalis. The same changes were observed in autotransplanted and homotransplanted kidneys and in kidneys in rejection. Our results suggest that high dosage of prednisone decreases the renal blood flow and this adverse effect has to be considered in the therapy. The administration of the drug directly into the arteria renalis may have to be avoided.

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On the Renal Site and Mode of Action of Glucocorticoid in Cirrhosis*

Cited by 14 publications

References 10 publications

Renal Tubular Effects of Hydrocortisone and Aldosterone in Normal Hydropenic Man: Comment on Sites of Action *

Renal Tubular Effects of Hydrocortisone and Aldosterone in Normal Hydropenic Man: Comment on Sites of Action *

Effect of Methylprednisolone on Renal Function and the Zonal Distribution of Blood Flow in the Rat

Effect of High-Dose Prednisone on Renal Hemodynamics of Normal and Transplanted Dog Kidneys

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