On the Road from Single-Atom Materials to Highly Sensitive Electrochemical Sensing and Biosensing

Jiao, Lei; Xu, Weiqing; Wu, Yu; Wang, Hengjia; Hu, Lili; Gu, Wenling; Zhu, Chengzhou

doi:10.1021/acs.analchem.2c01722

Cited by 36 publications

(14 citation statements)

References 72 publications

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“…3a). 34 The moieties of SACs (e.g., metal-N x ) can be applied as a redox mediator to amplify the signals and regulate the reaction pathways. 35 One advantage is the coordination between SAs and substrates.…”

Section: Electrochemical Sac-based Sensingmentioning

confidence: 99%

Single-atom catalysts: promotors of highly sensitive and selective sensors

Tian

Wang

et al. 2023

Chem. Soc. Rev.

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Section: Electrochemical Sac-based Sensingmentioning

confidence: 99%

Single-atom catalysts: promotors of highly sensitive and selective sensors

Tian

Wang

et al. 2023

Chem. Soc. Rev.

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“…For improving the catalytic activity of SACs, many strategies have been designed such as spatial confinement and heteroatom doping. As earlier reported, carbon materials (e.g., carbon nanotubes) and metal–organic frameworks are introduced to stabilize the SACs on their pores or channels at atomic scale, in turn preventing them from aggregation and inactivation …”

Section: Introductionmentioning

confidence: 99%

N-Doped Carbon Nanotubes Supported Fe–Mn Dual-Single-Atoms Nanozyme with Synergistically Enhanced Peroxidase Activity for Sensitive Colorimetric Detection of Acetylcholinesterase and Its Inhibitor

Mao

Zhang

et al. 2023

Anal. Chem.

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Monitoring acetylcholinesterase (AChE) and its inhibitors is of importance for early diagnosis and therapy of neurological diseases. Herein, N-doped carbon nanotubes supported Fe–Mn dual-single-atoms (FeMn DSAs/N-CNTs) were fabricated by a simple pyrolysis, as thoroughly figured out by a series of the characterization techniques. The peroxidase-like activity of FeMn DSAs/N-CNTs was investigated by catalytic oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to generate rich hydroxyl radicals (·OH) in the H2O2 system, which effectively catalyzed colorless TMB oxidation to blue oxidized TMB (ox-TMB). Besides, the peroxidase-like activity was greatly weakened by thiocholine (derived from AChE), accompanied by making blue ox-TMB fade. Impressively, the highly improved peroxidase-like property is further evidenced by density functional theory (DFT) calculations, where the dual-single atoms show a lower energy barrier (0.079 eV) and their interactions with the N-CNTs played critical roles for producing the oxygen radicals. By virtue of the nanozyme, a low-cost, specific, and sensitive colorimetric sensor was built for detection of AChE with a broader linear range of 0.1–30 U L–1 and a lower limit of detection (LOD, 0.066 U L–1), combined with its feasible analysis in human serum samples. Also, this platform was applied for measuring huperzine A inhibitor with a wide linear scope of 5–500 nM and a LOD down to 4.17 nM. This strategy provides a low-cost and convenient approach for early clinical diagnosis and drug development.

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“…In addition, it is observed that a higher fraction of surface atoms is present on smaller metal particles than that of larger metal particles, which has its impact not only on the proportion of catalytically active atoms of metal but also on selectivity. Therefore, increasing the dispersion of catalysts can considerably enhance the usage of active compounds and contribute to the development of sustainable catalytic technology. − Among them, copper SACs (Cu SACs) have been widely investigated for an extensive range of electrocatalytic applications, , such as carbon dioxide reduction reaction (CO 2 RR), oxygen reductin reaction (ORR), nitrogen reduction reaction (NRR), photocatalytic reactions, biotherapeutic applications, hydrogenation, environmental catalysis, coupling reactions, and others. The electrochemical processes that are driven by renewable electricity convert universal feedstocks (such as carbon dioxide, water, and nitrogen) into fuels as well as value-added chemicals (including ammonia, hydrogen, and hydrocarbons) via the electrochemical processes of water-splitting, CO 2 electroreduction, and N 2 electroreduction.…”

Section: Introductionmentioning

confidence: 99%

Recent Advancements in the Preparation and Application of Copper Single-Atom Catalysts

Syal

Kumar

Gupta

2023

ACS Appl. Nano Mater.

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Single-atom catalysts (SACs) have developed as a potential advanced variety of catalysts wherein copper SACs (Cu SACs) have appeared as a rising star in catalysis in which promising catalytic activity is achieved by a well-adjusted d-band center. Herein, the most recent advancements in the synthesis of copper SACs are highlighted. Various electrocatalytic applications such as carbon dioxide reduction reaction, oxygen reduction reaction, nitrogen reduction reaction, biotherapeutic applications, coupling reactions, hydroxylation, hydrogenation, photocatalytic reactions, and other miscellaneous reactions of Cu SACs coordinated into different supports have been thoroughly reviewed, and the stability and electrocatalytic performance of Cu SACs in fuel cells, zinc–CO2 batteries, and zinc–air batteries have been discussed. This review summarizes the study of most recent developments in the synthesis and applications of Cu SACs.

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On the Road from Single-Atom Materials to Highly Sensitive Electrochemical Sensing and Biosensing

Cited by 36 publications

References 72 publications

Single-atom catalysts: promotors of highly sensitive and selective sensors

Single-atom catalysts: promotors of highly sensitive and selective sensors

N-Doped Carbon Nanotubes Supported Fe–Mn Dual-Single-Atoms Nanozyme with Synergistically Enhanced Peroxidase Activity for Sensitive Colorimetric Detection of Acetylcholinesterase and Its Inhibitor

Recent Advancements in the Preparation and Application of Copper Single-Atom Catalysts

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