On the role of biogenic amines and reactive oxygen species in the disruption of the hypothalamic regulation of reproductive function in xenobiotic-induced and experimental hyperhomocysteinemia

Effects of prenatal hyperhomocysteinemia on hypothalamic regulation of estrous cycles were studied in female rats. In mature rats exposed to prenatal hyperhomocysteinemia, changes in the catecholamine content in hypothalamic areas responsible for the formation of the preovulatory surge of gonadotropin-releasing hormone were revealed: the level of norepinephrine in the medial preoptic area decreased and concentration of dopamine in the median eminence with arcuate nuclei increased. Administration of melatonin attenuated the observed changes, which can be related to neuroprotective effects of this hormone determined by its antioxidant properties.

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Prenatal Hyperhomocysteinemia Impairs Hypothalamic Regulation of Reproductive Cycles in Rat Progeny

Arutyunyan

Zaloznyaya

Керкешко

et al. 2017

Bull Exp Biol Med

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Disadaptive Disorders of Regulation of Functions with Aging

Артеменков

2019

Adv Gerontol

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On the role of biogenic amines and reactive oxygen species in the disruption of the hypothalamic regulation of reproductive function in xenobiotic-induced and experimental hyperhomocysteinemia

Cited by 2 publications

References 49 publications

Prenatal Hyperhomocysteinemia Impairs Hypothalamic Regulation of Reproductive Cycles in Rat Progeny

Prenatal Hyperhomocysteinemia Impairs Hypothalamic Regulation of Reproductive Cycles in Rat Progeny

Disadaptive Disorders of Regulation of Functions with Aging

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