On the role of components of therapeutic hydrophobic deep eutectic solvent-based nanoemulsions sustainably produced by membrane-assisted nanoemulsification for enhanced antimicrobial activity

Syed, Usman Taqui; Leonardo, Inês Carvalho; Mendoza, Gracia; Gaspar, Frédéric B.; Gámez, Enrique; Huertas, Rosa; Crespo, Maria Teresa Barreto; Arruebo, Manuel; Crespo, João G.; Sebastián, Víctor; Brazinha, Carla

doi:10.1016/j.seppur.2021.120319

Cited by 17 publications

(7 citation statements)

References 28 publications

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“…The observed trend is also coherent with the literature [ 49 ], which suggests that the high pressure transfers more mass to the droplet before detachment from the membrane surface and, therefore, increases the droplet size [ 50 ]. Moreover, the results depicted in Figure 3 are in accordance with the literature, wherein smaller dispersed phase flux offers better control over the emulsion droplets size and dispersity [ 19 , 51 , 52 ]. Bigger droplets and more oil passing through the membrane pores also favors the coalescence of the droplets, which is possibly another factor contributing to the observed large droplet sizes under high-pressure conditions.…”

Section: Resultssupporting

confidence: 88%

“…Several methods, such as high-shear mixers, high-pressure homogenizers and sonicators are reported in the literature for the formation of oil-in-water or water-in-oil emulsions. However, these methods are highly energy intensive and generally lack the ability to control the droplet size and distribution [ 18 , 19 ]. As much as 95% of the energy input is lost as heat, which can lead to the degradation of heat-sensitive ingredients [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Membrane Emulsification—A Novel Solution for Treatment and Reuse of Produced Water from Oil Field

et al. 2022

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Produced water (PW) is, by volume, the largest waste product of the oil- and gas-exploration industry and contains pollutants such as hydrocarbons and heavy metals. To meet the stringent environmental regulations, PW must be treated before discharging into the environment. The current study proposes a novel treatment method where PW is used to prepare oil-in-water emulsion with potential applications within the oil-exploration industry. The emulsions are prepared by applying hollow fiber membrane emulsification (ME) on PW, which inherently contains oil, as to-be-dispersed phase. The results demonstrate that the average droplet size of the emulsions is a function of pressure applied on to-be-dispersed phase and could be customized from 0.24 to 0.65 µm by varying the pressure from 0.25 to 1 bar, respectively. Stability of the emulsions was verified under high pressure and a temperature and storage period of more than 24 h. The calculations showed that an ME unit with <100 kg weight and <1 m3 volume is appropriate to transform the daily average volume of PW from the Danish part of the North Sea into the emulsions. The study provides a novel route, which also complies well with the requirements (low-weight and small spatial footprints) of the offshore oil rigs, to treat and reuse PW within the oil production process and, therefore, eliminates its environmental footprint.

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Section: Resultssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Membrane Emulsification—A Novel Solution for Treatment and Reuse of Produced Water from Oil Field

et al. 2022

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“…A reduced interfacial tension between the dispersed phase and the continuous phase used in a membrane emulsification study promotes the formation of emulsions [24]. Hence, the interfacial tension between the two phases was determined using a Drop Shape Analyzer (DSA 25B, Kruss GmbH, Hamburg, Germany).…”

Section: Characterisation Of the Optimised Phases And The Membrane Us...mentioning

confidence: 99%

“…This technique seems to be more effective in terms of productivity and energy consumption for producing emulsions with smaller sizes and controlled dispersity. Detailed comparison of membrane emulsification with traditional methods such as mechanical stirrers, homogenisers and ultrasonicators has been recently reported [19,[21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Design of Enzyme Loaded W/O Emulsions by Direct Membrane Emulsification for CO2 Capture

et al. 2022

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Membrane-based gas separation is a promising unit operation in a low-carbon economy due to its simplicity, ease of operation, reduced energy consumption and portability. A methodology is proposed to immobilise enzymes in stable water-in-oil (W/O) emulsions produced by direct membrane emulsification systems and thereafter impregnated them in the pores of a membrane producing emulsion-based supported liquid membranes. The selected case-study was for biogas (CO2 and CH4) purification. Upon initial CO2 sorption studies, corn oil was chosen as a low-cost and non-toxic bulk phase (oil phase). The emulsions were prepared with Nadir® UP150 P flat-sheet polymeric membranes. The optimised emulsions consisted of 2% Tween 80 (w/w) in corn oil as the continuous phase and 0.5 g.L−1 carbonic anhydrase enzyme with 5% PEG 300 (w/w) in aqueous solution as the dispersed phase. These emulsions were impregnated onto a porous hydrophobic PVDF membrane to prepare a supported liquid membrane for gas separation. Lastly, gas permeability studies indicated that the permeability of CO2 increased by ~15% and that of CH4 decreased by ~60% when compared to the membrane without carbonic anhydrase. Thus, a proof-of-concept for enhancement of CO2 capture using emulsion-based supported liquid membrane was established.

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“…It also presents the best dermal properties, and has shown several therapeutic properties as an analgesic, antitussive, antiviral or anticancer, among others [36]. A synergistic effect of the TM eutectic system as an antimicrobial agent has been observed [37]. Despite the similarity of the structures of its components, this system exhibits a nonideal unexpected behaviour [38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

Thymol+l-menthol eutectic mixtures: Thermophysical properties and possible applications as decontaminants

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Castro

Lafuente

et al. 2022

Journal of Molecular Liquids

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On the role of components of therapeutic hydrophobic deep eutectic solvent-based nanoemulsions sustainably produced by membrane-assisted nanoemulsification for enhanced antimicrobial activity

Cited by 17 publications

References 28 publications

Membrane Emulsification—A Novel Solution for Treatment and Reuse of Produced Water from Oil Field

Membrane Emulsification—A Novel Solution for Treatment and Reuse of Produced Water from Oil Field

Design of Enzyme Loaded W/O Emulsions by Direct Membrane Emulsification for CO2 Capture

Thymol+l-menthol eutectic mixtures: Thermophysical properties and possible applications as decontaminants

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