On the Role of Islet Amyloid Polypeptide in Glucose Intolerance and Anorexia of Pancreatic Cancer

Herrington, Margery K.; Arnelo, Urban; Permert, Johan

doi:10.1159/000055822

Pancreatology

2001

DOI: 10.1159/000055822

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On the Role of Islet Amyloid Polypeptide in Glucose Intolerance and Anorexia of Pancreatic Cancer

Margery K. Herrington

Urban Arnelo

Johan Permert

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Cited by 4 publications

(1 citation statement)

References 139 publications

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“…2e–f). We next examined secreted factors reported to be elevated in late-stage PDAC and/or known to induce cachexia in other models 4,16 and found no differences between control and early KP−/−C mice (Extended Data Fig. 2).…”

mentioning

confidence: 99%

Altered exocrine function can drive adipose wasting in early pancreatic cancer

Danai

Babić

Rosenthal

et al. 2018

Nature

124

114

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Malignancy is accompanied by changes in the metabolism of both cells and the organism. Pancreatic ductal adenocarcinoma (PDAC) is associated with wasting of peripheral tissues, a metabolic syndrome that lowers quality of life and has been proposed to decrease survival of patients with cancer. Tissue wasting is a multifactorial disease and targeting specific circulating factors to reverse this syndrome has been mostly ineffective in the clinic. Here we show that loss of both adipose and muscle tissue occurs early in the development of pancreatic cancer. Using mouse models of PDAC, we show that tumour growth in the pancreas but not in other sites leads to adipose tissue wasting, suggesting that tumour growth within the pancreatic environment contributes to this wasting phenotype. We find that decreased exocrine pancreatic function is a driver of adipose tissue loss and that replacement of pancreatic enzymes attenuates PDAC-associated wasting of peripheral tissues. Paradoxically, reversal of adipose tissue loss impairs survival in mice with PDAC. When analysing patients with PDAC, we find that depletion of adipose and skeletal muscle tissues at the time of diagnosis is common, but is not associated with worse survival. Taken together, these results provide an explanation for wasting of adipose tissue in early PDAC and suggest that early loss of peripheral tissue associated with pancreatic cancer may not impair survival.

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mentioning

confidence: 99%

Altered exocrine function can drive adipose wasting in early pancreatic cancer

Danai

Babić

Rosenthal

et al. 2018

Nature

124

114

View full text Add to dashboard Cite

show abstract

Should pancreas imaging be recommanded in patients over 50 years when diabetes is discovered because of acute symptoms?

Damiano

Bordier

Berre

et al. 2004

Diabetes & Metabolism

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Approaches to Study Tumor Metabolism in Mice

Gultekin,

Vander Heiden,

Lien

2023

Cold Spring Harb Perspect Med

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On the Role of Islet Amyloid Polypeptide in Glucose Intolerance and Anorexia of Pancreatic Cancer

Cited by 4 publications

References 139 publications

Altered exocrine function can drive adipose wasting in early pancreatic cancer

Altered exocrine function can drive adipose wasting in early pancreatic cancer

Should pancreas imaging be recommanded in patients over 50 years when diabetes is discovered because of acute symptoms?

Approaches to Study Tumor Metabolism in Mice

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