On the role of the dopaminergic system in the memory deficits induced by maternal deprivation

Neves, Ben-Hur Souto das; Barbosa, Gabriel Palermo Del Rosso; Rosa, Ana Carolina de Souza da; Picua, Steffanie Severo; Gomes, Gabriela Mendes; Sosa, Priscila Marques; Mello‐Carpes, Pâmela Billig

doi:10.1016/j.nlm.2020.107272

Cited by 12 publications

(12 citation statements)

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“…The drug concentrations were as follows: SKF 38393, 12.5 μg/μl; SCH 23390, 1 μg/μl; Rp‐cAMP, .5 μg/μl; Sp‐cAMP, .5 μg/μl; Gö 6976, 1.7 ng/μl; and PMA, .5 μg/μl. The concentrations and volumes were based on previous studies showing each compound's effect on learning and behavioural performance (Furini et al, 2014; Menezes et al, 2015; Neves et al, 2020; Vargas et al, 2020).…”

Section: Methodsmentioning

confidence: 99%

“…The infusion procedures were based on previous studies by our research group (Lima et al, 2019; Lima et al, 2021; Menezes et al, 2015; Neves et al, 2020; Vargas et al, 2020). For the infusion, a Hamilton syringe was connected to fine bore polythene tubing (38 gauge) with an infusion needle (30 gauge) at the end.…”

Section: Methodsmentioning

confidence: 99%

“…Cannula placement was verified post‐mortem as described previously (de Vargas et al, 2017; Neves et al, 2020). Two to four hours after the last behavioural test, we injected into the CA1 region 1 μl per side of 4% methylene blue solution.…”

Section: Methodsmentioning

confidence: 99%

“…Whereas D1 subtype receptors indirectly modulate protein kinase A (PKA) by adenylyl cyclase (AC) activation, D5 subtype receptors seem to regulate protein kinase C (PKC) activity through positive coupling to the phosphatidylinositol‐3‐kinase system (Undieh, 2010). In this sense, distinguishing between D1 and D5 receptors is pharmacologically possible by modulating these two pathways (Furini et al, 2014; Lima et al, 2021; Menezes et al, 2015; Neves et al, 2020). Interestingly, when evaluated individually, the D1 receptors subtype is more relevant than D5 in modulatory effect on different types of memory (Lima et al, 2021; Menezes et al, 2015; Neves et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…In this sense, distinguishing between D1 and D5 receptors is pharmacologically possible by modulating these two pathways (Furini et al, 2014; Lima et al, 2021; Menezes et al, 2015; Neves et al, 2020). Interestingly, when evaluated individually, the D1 receptors subtype is more relevant than D5 in modulatory effect on different types of memory (Lima et al, 2021; Menezes et al, 2015; Neves et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Novelty promotes recognition memory persistence by D1 dopamine receptor and protein kinase A signalling in rat hippocampus

Lima

Rosa

Picua

et al. 2021

Eur J of Neuroscience

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Strategies for improving memory are increasingly studied, and exposure to a novel experience can be an efficient neuromodulator. Novelty effects on memory depend on D1‐family dopamine receptors (D1Rs) activation. Here, we evaluated the novelty effect on memory persistence of Wistar rats and investigated the contribution of D1Rs and their signalling pathways by protein kinase A (PKA) and C (PKC). Animals with infusion cannulae inserted into the CA1 hippocampus area were trained on the novel object recognition (NOR) task, which involved exploring two different objects. After training, some rats received intrahippocampal infusions of vehicle or D1Rs agonist; others explored a novel environment for 5 min and were infused with a variety of drugs targeting D1Rs and their signalling pathways. We demonstrated that pharmacological stimulation of D1Rs or novelty exposure promoted NOR memory persistence for 14 days and that the novelty effect depended on D1Rs activation. To determine if the D1 and D5 receptor subtypes were necessary for the impact of novelty exposure on memory, we blocked or stimulated PKA or PKC—protein kinases activated mainly by D1 and D5, respectively. Only PKA inhibition impaired the effect of novelty on memory persistence. After novelty and D1Rs blocking, PKA but not PKC stimulation maintained the memory persistence effect. Thus, we concluded that novelty promoted memory persistence by a mechanism‐dependent on activating hippocampal D1Rs and PKA pathway.

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