Direct-sequence code division multiple access (DS-CDMA) is a promising uplink access technology for broadband cellular mobile communication systems. In this paper, we propose a joint transmit (Tx)/iterative receive (Rx) frequency-domain equalization (FDE) for DS-CDMA. In the proposed scheme, simple one-tap FDE at the transmitter and iterative one-tap FDE at the receiver are jointly performed using the common knowledge of channel state information (CSI). Before transmitting the signal, the transmitter predicts the degree of residual inter-chip interference (ICI) power after the iterations of Rx FDE to determine the Tx FDE weight while the receiver performs the iterative Rx FDE. In practice, it is almost impossible to share the perfect knowledge of CSI. In this paper, a Gaussian approximation of channel estimation (CE) errors is introduced. We theoretically derive a set of Tx and iterative Rx FDE weights based on the minimum mean square error (MMSE) criterion in the presence of the CE error. We show by computer simulation that the proposed scheme provides better bit error rate (BER) performance than the conventional scheme which uses iterative Rx FDE only (i.e., without Tx FDE) even in the presence of CE error.square error (MMSE) frequency-domain equalization (FDE) can be applied to suppress the ICI and hence, improve the BER performance [3][4][5][6][7][8]. However, the performance improvement is limited due to the presence of residual ICI after Rx FDE.Recently, iterative Rx FDE scheme [9,10] was proposed for DS-CDMA [8,11] to improve the BER performance by suppressing the residual ICI after Rx FDE. In this scheme, at first, a series of one-tap Rx FDE, despreading, and channel decoding is carried