On the study of polyurethane Ionomer—Part I

Chwang, C. P.; Wang, C. L.; Kuo, Y. M.; Lee, S. N.; Chao, Albert; Chao, D. Y.

doi:10.1002/pat.187.abs

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“…In ionic metal containing polymers, the ionic charges in the polymer creates physical crosslinking between the polymer chains, preventing chain slippage during loading thereby increasing the mechanical property of the polyurethane. It was also noticed that ionic forces enhances the cohesion of the polyol unit under stress resulting in increase in modulus and elongation at break 25. Sufficiently good mechanical strength makes this electrospun scaffold a potential candidate for various biomedical applications.…”

Section: Discussionmentioning

confidence: 94%

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Electrospun biodegradable calcium containing poly(ester‐urethane)urea: Synthesis, fabrication, in vitro degradation, and biocompatibility evaluation

Nair

Ramesh

2012

J Biomedical Materials Res

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In this work an in vitro degradable poly(ester-urethane)urea (PEUU) was synthesized using polycaprolactone diol, hexamethylene diisocyanate, and calcium salt of p-aminobenzoic acid. The synthesized polymer was characterized by (1) H-NMR and FTIR spectroscopy and viscosity studies. Scaffolds having random micro fibrous structures were fabricated from PEUU by electrospinning process. The thermal properties of the scaffold were evaluated by thermogravimetric analysis and dynamic mechanical analysis. The mechanical property evaluation showed that the scaffold possess sufficiently high tensile strength of 16 MPa. The in vitro degradation studies of the electrospun scaffold were carried out in phosphate buffer saline for 6 months. The average mass loss of the scaffold after 6 months of hydrolytic degradation was 25%. FTIR spectroscopy study confirmed the degradation of the PEUU from decrease in intensity of 1400 cm(-1) peak corresponding to ionic carboxylate group. Presence of amine group and calcium ions in the degradation medium further confirmed the degradation of the hard segment in the hydrolytic medium. The mechanical property evaluation of the scaffold indicated a gradual decrease in tensile strength and modulus whereas percentage elongation of the scaffold increases with time of in vitro degradation. The morphological evaluation of the scaffold after degradation by SEM shows evidence of broken fibers and pores in the scaffold. Preliminary in vitro cytotoxicity test demonstrated that both the material and the degradation products were noncytotoxic in nature and the material showed good proliferation to L-929 cells.

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Section: Discussionmentioning

confidence: 94%

“…It was also noticed that ionic forces enhances the cohesion of the polyol unit under stress resulting in increase in modulus and elongation at break. 25 Sufficiently good mechanical strength makes this electrospun scaffold a potential candidate for various biomedical applications.…”

Section: Discussionmentioning

confidence: 99%

Electrospun biodegradable calcium containing poly(ester‐urethane)urea: Synthesis, fabrication, in vitro degradation, and biocompatibility evaluation

Nair

Ramesh

2012

J Biomedical Materials Res

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On the study of polyurethane Ionomer—Part I

Cited by 1 publication

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Electrospun biodegradable calcium containing poly(ester‐urethane)urea: Synthesis, fabrication, in vitro degradation, and biocompatibility evaluation

Electrospun biodegradable calcium containing poly(ester‐urethane)urea: Synthesis, fabrication, in vitro degradation, and biocompatibility evaluation

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