On the suitability of nanocrystalline ferrites as a magnetic carrier for drug delivery: Functionalization, conjugation and drug release kinetics

Rana, Subhasis; Gallo, August A.; Srivastava, R. S.; Misra, R.D.K.

doi:10.1016/j.actbio.2006.10.006

Cited by 282 publications

(130 citation statements)

References 37 publications

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“…The properties of ferrite nanoparticles can be altered by controlling their size, which can provide an advantage in formulating new composite materials with optimized properties for various applications. Thus, to control the growth of the spinel ferrite nanoparticles, organic stabilizers (polymers), e.g., polyvinyl alcohol (PVA), polyethylene oxide (PEO), polymethacrylic acid (PMAA), and poly(vinyl pyrrolidone) (PVP), are added during the synthesis for capping the surface of the particles [14,15]. In our previous work [16], a thermal-treatment method was used to prepare zinc ferrite (ZnFe 2 O 4 ) nanoparticles from an aqueous solution that contained metal nitrates, PVP, and deionized water.…”

Section: Introductionmentioning

confidence: 99%

A Novel Research on Behavior of Zinc Ferrite Nanoparticles in Different Concentration of Poly(vinyl pyrrolidone) (PVP)

Kamari

Naseri

Saion

2014

Metals

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Zinc ferrite nanocrystals were prepared from an aqueous solution containing metal nitrates and various of concentrations of poly(vinyl pyrrolidone) (PVP), i.e., 0, 15, 40, and 55 g/L, as a capping agent. To stabilize the particles, they were thermally treated at 873 K, as an optimum calcination temperature. The behaviors of the polymeric precursor were analyzed by use of simultaneous thermo-gravimetry (TG) and derivative thermo-gravimetry analyses (DTG). The presence of the crystalline phase in each sample was confirmed by X-ray diffraction (XRD) analysis. The average particle size and the morphology of the nanoparticles were determined by transmission electron microscopy (TEM), and these parameters were found to differ at various concentrations of PVP. Fourier transform infrared spectroscopy (FT-IR) confirmed the presence of metal oxide bands for all the PVP concentrations and confirmed the absence of organic bands for PVP concentrations less than 55 g/L. Measurements of the magnetization value of the zinc ferrite nanoparticles were obtained at room temperature by using a vibrating sample magnetometer (VSM), which showed that, in the absence of PVP, the sample exhibited a paramagnetic behavior while, in the presence of PVP, samples have a super-paramagnetic behavior.

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Section: Introductionmentioning

confidence: 99%

A Novel Research on Behavior of Zinc Ferrite Nanoparticles in Different Concentration of Poly(vinyl pyrrolidone) (PVP)

Kamari

Naseri

Saion

2014

Metals

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“…Due to the interesting magnetic and electrical properties with good chemical and thermal stabilities, spinal ferrite nanoparticles such as nickel ferrite are used in bioapplications including magnetic resonance imaging, drug delivery and hyperthermia [33][34][35][36][37]. However, little is known about the toxicity of spinal ferrite nanoparticles at the cellular and molecular levels.…”

Section: Description Of Finding In Vivomentioning

confidence: 99%

Nanoparticles Toxicity and Their Routes of Exposures

Aydın¹,

Sipahi²,

Charehsaz³

2012

Recent Advances in Novel Drug Carrier Systems

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“…The presence of Pluronic F-68 on the surface of magnetic nanoparticles can be considered as a magnetic dead layer, thus affecting the saturation magnetization as a result of quenching of the surface moment. 29 Drug release profile through polymeric nanoaggregates as a function of different formulation parameters…”

Section: Particle Size and Morphologymentioning

confidence: 99%

Controlled release of 5-fluorouracil and progesterone from magnetic nanoaggregates

Ragab¹,

Rohani²,

Consta³

2012

IJN

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Background:The potential use of magnetic nanoparticles in biomedical applications has witnessed an exponential growth in recent years. Methods: In this study, we used nanoaggregates of magnetic nanoparticles as carriers for controlled drug delivery. The nanoaggregates are formed due to the presence of the block copolymer of polyethylene oxide-polypropylene oxide (Pluronic F-68) and beta-cyclodextrin that surround the magnetic core of the nanoparticles. The administration of the drug carriers occurs by inhalation, and the drug is delivered systemically via the pulmonary route. We tested the delivery of 5-fluorouracil and progesterone, which are used as models of hydrophilic and hydrophobic drugs, respectively. Results: The estimated nanoaggregates' diameters are between 293 nm ± 14.65 nm and 90.2 nm ± 4.51 nm, respectively. In-situ and post-synthesis techniques are two approaches for drug loading. The polymer composition of nanoaggregates and initial drug concentration showed a significant effect on both the drug entrapment efficiency and release kinetics. Average drug entrapment efficiencies ranged between 16.11% and 83.25%. In-situ loaded samples showed significantly slower release rates. The drug release mechanism is investigated by mathematical curve fitting to different drug release kinetics models. In most cases, the Peppas model has shown good correlations (coefficients of correlation, R 2 , between 0.85 and 0.99) with the examined release profiles. The estimated release indices are below 0.5, which indicates the Fickian diffusion mechanism. For samples with an initial burst effect, the modified Peppas model can provide a better understanding of the drug release mechanism, both in the samples loaded with progesterone, or those high polymer concentrations. Conclusion: Our work showed prolonged delivery of drugs (5-fluorouracil and progesterone) by diffusion from nanoaggregates, with the potential to reduce dose-related adverse effects.

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On the suitability of nanocrystalline ferrites as a magnetic carrier for drug delivery: Functionalization, conjugation and drug release kinetics

Cited by 282 publications

References 37 publications

A Novel Research on Behavior of Zinc Ferrite Nanoparticles in Different Concentration of Poly(vinyl pyrrolidone) (PVP)

A Novel Research on Behavior of Zinc Ferrite Nanoparticles in Different Concentration of Poly(vinyl pyrrolidone) (PVP)

Nanoparticles Toxicity and Their Routes of Exposures

Controlled release of 5-fluorouracil and progesterone from magnetic nanoaggregates

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