On the synthesis of new amphiphilic entities by the succinic coupling of β-cyclodextrins to calixarenes

Abstract

Novel molecules, composed of a β-cyclodextrin coupled via a succinic diamide linker to di-n-octyl-calix[4]arene monocrown-6 or to biscrown-6-calix[4]arene, were synthesized by two independent routes: from mono-6′-deoxy-6′-amino-β-cyclodextrin, and from tetraaminocalix[4]arene derivatives. Key words: β-cyclodextrin–calix[4]arene coupling, aminosuccinate-β-CD, aminosuccinate-calix[4]arene, octyloxy-calix[4]arene–monocrown-6, calix[4]arene–biscrown-6.

Polycaprolactone/Amino-β-Cyclodextrin Inclusion Complex Prepared by an Electrospinning Technique

“…The first stage of this work was the synthesis of the β-cyclodextrin amine derivative with a final yield after its purification of 0.4, which is in accordance with other works [ 27 , 28 , 29 , 30 ]. The product was characterized by spectroscopic methods like FT-IR, mass spectrometry and 1 HNMR.…”

Physico-chemical investigation of asymmetrical peptidolipidyl-cyclodextrins

“…These molecules take the shape of a truncated cone with an internal hydrophobic cavity, which makes them very attractive as supramolecular building blocks [1][2][3]. CDs are extensively studied in a variety of research subjects including encapsulation [1], amphiphilic structure [2], chromatography [3], molecular recognition [4], biomaterials [5,6]. CDs are well known for their ability to interact with lipophilic molecules to form noncovalent inclusion complexes [7][8][9].…”

On the synthesis of cyclodextrin–peptide conjugates by the Huisgen reaction

“…25% yield . Next, the tosyl group was substituted in near‐quantitative yield by sodium azide, leading to 1 (Scheme ) .…”