On the synthesis of pyrido[3,2,1‐kl]phenothiazine, quino[8,1‐bc][1,4]benzothiazepine and their derivatives

Abstract

This review article comprises tetracyclic rigid analogues of phenothiazine and dibenzothiazepine derivatives. In order to discover new useful drugs, the side chain of the heterocyclic nucleus is incorporated into a ring forming tetracyclic compounds. The text has been divided in thirteen sections.

Access to Phenothiazine Derivatives via Iodide-Mediated Oxidative Three-Component Annulation Reaction

“…Known product, light yellow liquid, PE as the eluent, 33.6 mg, 56% yield; 1 H NMR (400 MHz, CDCl 3 ) δ 7.20–7.10 (m, 2H), 6.95 (t, J = 7.6 Hz, 2H), 6.91–6.80 (m, 3H), 3.76–3.66 (m, 2H), 2.79 (t, J = 6.0 Hz, 2H), 2.18 (p, J = 5.9 Hz, 2H); 13 C­{ 1 H} NMR (101 MHz, CDCl 3 ) δ 144.7, 141.3, 127.9, 127.4, 127.0, 125.3, 125.1, 122.3, 121.9, 121.8, 120.2, 112.8, 47.0, 28.2, 21.8; IR (KBr) 3060, 2930, 2857, 1655, 1579, 1438, 1316, 1184, 1103, 740, 603, 490 cm –1 ; MS (EI, m / z ) 239.1 [M] + .…”

Synthesis and structure of new 3,7,10-substituted-phenothiazine derivatives

“…Phenothiazine and its derivatives exhibit many applications as pharmaceuticals, in material sciences and biochemistry [1][2][3][4][5]. Many phenothiazine derivatives are fluorescent, show a low oxidation potential having the ability to form stable radical-cations, and are used as chromophores for photoinduced electron transfer experiments [2,6].…”