“…Since the canonical axis of a hexagonal prism passes perpendicularly through its two hexagonal faces, by embedding the Diels−Alder TS in a hexagonal prism, the prism's axis is transferred to the TS (see Figure 2C). Moreover, studies suggest 23,24 degree of closeness between the object and the observer salient features 23,24 salient, distinguishable forms or shapes that observers can use to recognize the representation of an object canonical axis 34 axis from which it feels natural to rotate, translate, or elongate a shape depth cues 20,22,28 depth perception cues that depict 3D spatial characteristics in 2D representations (for example, relative size, angle distortions, foreshortening lines) oblique orientations 21 The impression of three-dimensionality is more easily recognized in oblique orientations. that canonical axes help observers to visualize 3D characteristics because from this axis, observers can project two perpendicular axes, creating an internal reference frame (see Figure 2D).…”