Advanced ventilation methods are responsible for creating an appropriate temperature environment with satisfactory inhaled air quality. The ductless personalized ventilation system integrated with impinging jet ventilation shows the good ventilation performance. In order to investigate the effect of using such an integrated system on thermal comfort and air quality improvement. Twenty subjects participated in a chamber test at 25 °C, 27 °C, and 29 °C, respectively, with operating DPV devices at three modes (no flow, pre-set flow, and user control flow). Votes on thermal comfort, thermal sensation, thermal acceptability, and perceived air quality were collected from the them. The results showed that overall thermal sensation votes with DPV running at the user control flow mode were close to neutral (0.1, 0.4, and 0.5, respectively, at 25 °C, 27 °C, and 29 °C). Thermal comfort and perceived air quality were improved at all three temperatures studied in the user control DPV flow mode, with 90% of occupants reporting that the thermal environments were acceptable. An integrated system of this type could raise the acceptable HVAC temperature setpoint to 29 °C, resulting in an average energy savings of 34% over the neutral condition at 25 °C. Hence, occupants are advised to use the DPV’s user-control mode. Lastly, it is concluded that the integrated system could greatly improve thermal comfort, perceived air quality, and save HVAC energy, despite some issues with dry eyes at 29 °C.