A numerical study on the elastic response of single-and multi-layer systems formed by alternating pentamode lattices and stiffening plates is presented. Finite element simulations are conducted to analyze the dependence of the effective elastic moduli of such structures upon suitable aspect ratios, which characterize the geometry of the generic pentamode layer at the micro-and macro-scale, and the lamination scheme of the layered structure. The given numerical results highlight that the examined structures exhibit bending-dominated response, and are able to achieve low values of the effective shear modulus and, contemporarily, high values of the effective compression modulus. We are lead to conclude that confined pentamode lattices can be regarded as novel metamaterials that are well suited for seismic isolation and impact protection purposes. Their elastic response can be finely tuned by playing with several geometrical and mechanical design variables.