Shallow shear-wave velocities (VS) sometimes are estimated from joint inversions of horizontal-to-vertical (H/V) spectral ratios and surface-wave dispersion curves derived from ambient noise or small active sources. Here, we evaluate carrying out these inversions using Rayleigh-wave dispersion curves computed from crustal-scale P-wave seismic refraction data. We use data from the 2014–2015 Eastern North American Margin (ENAM) experiment in Virginia and North Carolina, but similar seismic refraction data sets have been acquired over sedimentary basins of interest for seismic hazard studies, including in major urban areas. The ENAM project deployed a pair of ∼215 km long, northwest–southeast linear arrays with ∼300 m receiver spacing to record 11 dynamite shots, and 80 continuously recording seismometers with 5–6 km spacing along the same arrays to record offshore airguns. The arrays crossed the onland portion of the Atlantic Coastal Plain sediments, which are a seaward-thickening wedge of Cretaceous and younger sediments deposited mostly on crystalline bedrock. We compute Rayleigh-wave dispersion curves from 3 to 9 km long portions of the receiver arrays on each side of the dynamite shots, and we compute ambient-noise H/V ratios from the continuously recording seismometers. We use a genetic inversion algorithm in which forward velocity models in each “generation” are evaluated for misfits compared to the observed data, with subsequent generations constructed from the models with the smallest misfits. Velocities to depths of 500 m are defined well, as shown by a narrow range of velocities in the best-fit models, by the consistency between multiple inversion runs at a site, and by forward modeling of site responses. The resulting velocity cross-section of the Coastal Plain strata has seaward-dipping contours in the thinner portions of the Coastal Plain but smaller dips in the deeper portions. We interpret these results as showing that velocity contours in the ACP strata are influenced by a combination of lithology and overburden pressure. Results demonstrate that existing seismic refraction data have the potential for determining detailed shallow shear-wave velocity profiles.