On the venom of the lesser weeverfish,<i>Trachinus vipera</i>

Carlisle, D. B.

doi:10.1017/s0025315400001284

Cited by 28 publications

(9 citation statements)

References 10 publications

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“…Though proteinaceous toxins and enzymes appear to be the major components in piscine venoms, there is evidence that they contain non-proteinaceous active compounds. For example, a dialyzable fraction from T. vipera venom was found to contain 5-hydroxytryptamine (5-HT), commonly known as serotonin, which is well known as a nociceptive compound [ 164 ]. G. marmoratus venom was also found to contain 5-HT, or a 5-HT-like substance, that was found to act directly at 5-HT receptors and whose action was attenuated by a 5-HT receptor antagonist [ 76 ].…”

Section: Venom Componentsmentioning

confidence: 99%

Bioactive Components in Fish Venoms

Ziegman

Alewood

2015

Toxins

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Animal venoms are widely recognized excellent resources for the discovery of novel drug leads and physiological tools. Most are comprised of a large number of components, of which the enzymes, small peptides, and proteins are studied for their important bioactivities. However, in spite of there being over 2000 venomous fish species, piscine venoms have been relatively underrepresented in the literature thus far. Most studies have explored whole or partially fractioned venom, revealing broad pharmacology, which includes cardiovascular, neuromuscular, cytotoxic, inflammatory, and nociceptive activities. Several large proteinaceous toxins, such as stonustoxin, verrucotoxin, and Sp-CTx, have been isolated from scorpaenoid fish. These form pores in cell membranes, resulting in cell death and creating a cascade of reactions that result in many, but not all, of the physiological symptoms observed from envenomation. Additionally, Natterins, a novel family of toxins possessing kininogenase activity have been found in toadfish venom. A variety of smaller protein toxins, as well as a small number of peptides, enzymes, and non-proteinaceous molecules have also been isolated from a range of fish venoms, but most remain poorly characterized. Many other bioactive fish venom components remain to be discovered and investigated. These represent an untapped treasure of potentially useful molecules.

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Section: Venom Componentsmentioning

confidence: 99%

Bioactive Components in Fish Venoms

Ziegman

Alewood

2015

Toxins

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“…It shows pro-inflammatory effects by increasing rolling leukocyte numbers in the mouse cremaster muscle postcapillary venules [71]. Porflan does not cross biological membranes unassisted and therefore may target active transport and extracellular domains to elicit activity [72] (table 4).…”

Section: Porflanmentioning

confidence: 99%

The FISH VENOM TOXINS: NATURAL SOURCE OF PHARMACEUTICALS AND THERAPEUTIC AGENTS “PHARMACEUTICAL AND THERAPEUTIC USES OF FISH VENOM TOXINS

Pandey

Upadhyay

2020

Int J Pharm Pharm Sci

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The present review article explains fish toxins from different species with their pharmaceutical and therapeutic uses. Fish stinging is a major problem in coastal areas as it exerts severe toxic effects mainly in fishermen, locals, and tourists. Fish toxins cause severe pain that radiates up in the limbs and regional lymphatics. These also impose venular stasis, hemorrhage and make changes in the arteriolar wall diameter. Fish toxins target ion-channels, ligand-gated channels and G-protein coupled receptors present in body cells and obstructs their physiological and metabolic functions. They affect molecules that participate in signaling pathways, and cause hemolytic, cardiovascular, and make obstruction in nerve function and smooth muscle contraction. For quick neutralization, fish venom-induced effects in victim’s toxin-specific antibodies are used. These quickly provide relief from pain, minimize the symptoms, and stop the immediate inflammatory reaction. Fish venom toxins are of wider biomedical applications and can be used for the preparation of immune diagnostics, bio-pesticides, anticancer agents, and analgesics by using its biological information.

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“…Trakonya balık-larının dikenlerini beslenme için kullandıklarına dair her hangi bir bulgu yoktur. Laboratuvar ortamında yapılan deneylerde saklandıkları yerden avlarını saldırarak yakaladıkları ve dikenlerini yalnızca savunma amaçlı kullandıkları bildirilmiştir (Carlisle, 1962).…”

Section: Zehi̇r Ve Toksi̇k Etki̇ Mekani̇zmalariunclassified

Toxic Effects of Weever Fishes among Poisonous Fishes along the Coast of Turkey

Yıldız¹,

Karakulak²

2018

Aquat Sci Eng

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ÖZBu derleme çalışmasında ülkemiz kıyılarında dağılım gösteren trakonya balıklarının zehir ve toksik etki mekanizmaları ile tedavi yolları irdelenmiştir. Trakonya zehri, solungaç kapağı üzerinde bulunan operkül-er dikende ve 1.dorsal yüzgeçte bulunan 5-8 dorsal dikende bulunur. Trakonya zehirlenmeleri ani bir ağrı, yanma ve iğneleme şeklinde ortaya çıkmaktadır. Bu bulguların süresi hastaya, balığın cinsine ve mevsimlere göre değişmektedir. Halk arasında bilinenin aksine acil servis müdahalesi olarak soğuk su yerine etkilenen bölgenin 60-90 dakika yaklaşık 40 o C veya daha sıcak suya daldırılması gerekmektedir.Anahtar Kelimeler: Zehirli balıklar, trakonya, ilk yardım ABSTRACTIn this review, the mechanism of action of poisons and toxic effects of and treatment methods for the same among weever fishes, which are present along the coast of Turkey, were addressed. Weever fish poison is present in the spicule located on the operculum and in the 5 th -8 th dorsal spines located on the first dorsal fin. Weever fish poisoning is identified through symptoms of intense pain, burning, and stinging. The duration of these symptoms varies among patients and depends on the species and season. Contrary to common belief, instead of immersion in cold water, immersion in hot water at about ≥40°C is used during emergencies.

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On the venom of the lesser weeverfish,Trachinus vipera

Cited by 28 publications

References 10 publications

Bioactive Components in Fish Venoms

Bioactive Components in Fish Venoms

The FISH VENOM TOXINS: NATURAL SOURCE OF PHARMACEUTICALS AND THERAPEUTIC AGENTS “PHARMACEUTICAL AND THERAPEUTIC USES OF FISH VENOM TOXINS

Toxic Effects of Weever Fishes among Poisonous Fishes along the Coast of Turkey

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