2018
DOI: 10.3389/fneur.2018.00602
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On the Viability and Potential Value of Stem Cells for Repair and Treatment of Central Neurotrauma: Overview and Speculations

Abstract: Central neurotrauma, such as spinal cord injury or traumatic brain injury, can damage critical axonal pathways and neurons and lead to partial to complete loss of neural function that is difficult to address in the mature central nervous system. Improvement and innovation in the development, manufacture, and delivery of stem-cell based therapies, as well as the continued exploration of newer forms of stem cells, have allowed the professional and public spheres to resolve technical and ethical questions that pr… Show more

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Cited by 17 publications
(14 citation statements)
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References 364 publications
(334 reference statements)
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“…While numerous preclinical studies have demonstrated positive NPC-mediated effects on nervous system regeneration, [2,22] the predominant role played by NPCs is often unclear and may vary based on the therapeutic target. [23] In some instances, NPCs are believed to aid in regeneration by differentiating into mature cell types such as neurons and oligodendrocytes and directly re-placing damaged or diseased tissue.…”
Section: Implications For Materials Applied To Npc Therapiesmentioning
confidence: 99%
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“…While numerous preclinical studies have demonstrated positive NPC-mediated effects on nervous system regeneration, [2,22] the predominant role played by NPCs is often unclear and may vary based on the therapeutic target. [23] In some instances, NPCs are believed to aid in regeneration by differentiating into mature cell types such as neurons and oligodendrocytes and directly re-placing damaged or diseased tissue.…”
Section: Implications For Materials Applied To Npc Therapiesmentioning
confidence: 99%
“…[23] In some instances, NPCs are believed to aid in regeneration by differentiating into mature cell types such as neurons and oligodendrocytes and directly re-placing damaged or diseased tissue. [2] Such outcomes would be highly desirable for conditions characterized by significant death of a particular neuronal cell type, as occurs in many neurodegenerative diseases. On the other hand, NPCs are also known to secrete neurotrophic factors that modulate the host cell response to injury, and this paracrine effect can drive tissue regeneration without relying on the differentiation and integration of transplanted NPCs into the host tissue.…”
Section: Implications For Materials Applied To Npc Therapiesmentioning
confidence: 99%
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“…NPC transplantation has been combined with ex vivo gene delivery for expression of regeneration-promoting molecules. So far, several studies have addressed the efficacy of transplanting embryonic stem cells preconditioned to restrict their differentiation to neural lineages as well as neural stem/precursor cells from the embryonic or adult CNS into animal models of brain and spinal cord injury [9294]. Additionally, a number of molecules have been used to enhance the capacity of embryonic stem cells and NPCs to repair CNS damage in animal models of brain injury.…”
Section: Cend1 As a Valuable Gene Therapy Toolmentioning
confidence: 99%
“…The central nervous system (CNS) injury can always cause sensory and motor dysfunction, which has been difficult to overcome in the regenerative field [1]. Since nerve tissue engineering developed fast in the past years, neurobiological materials are chosen to treat CNS injury as a new strategy [2][3][4][5].…”
Section: Introductionmentioning
confidence: 99%