The classical Jacobian Conjecture asserts that every locally invertible polynomial self-map of the complex affine space is globally invertible. A Keller map is a (hypothetical) counterexample to the Jacobian Conjecture. In dimension two every such map, if exists, leads to a map between the Picard groups of suitable compactifications of the affine plane, that satisfy a complicated set of conditions. This is essentially a combinatorial problem. Several solutions to it ("frameworks") are described in detail. Each framework corresponds to a large system of equations, whose solution would lead to a Keller map.