On Uniqueness of a Cycle in One Circular Gene Network Model

Golubyatnikov, V. P.; Minushkina, L. S.

doi:10.1134/s0037446622010062

Cited by 2 publications

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“…Similar constructions can be done for a block-linear analogue of the six-dimensional Elowitz-Leibler system (Elowitz, Leibler, 2000) studied in (Minushkina, 2021;Golubyatnikov, Minushkina, 2022)…”

Section: And Its Decomposition To Blocksmentioning

confidence: 81%

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Stratifications and foliations in phase portraits of gene network models

et al. 2023

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Periodic processes of gene network functioning are described with good precision by periodic trajectories (limit cycles) of multidimensional systems of kinetic-type differential equations. In the literature, such systems are often called dynamical, they are composed according to schemes of positive and negative feedback between components of these networks. The variables in these equations describe concentrations of these components as functions of time. In the preparation of numerical experiments with such mathematical models, it is useful to start with studies of qualitative behavior of ensembles of trajectories of the corresponding dynamical systems, in particular, to estimate the highest likelihood domain of the initial data, to solve inverse problems of parameter identification, to list the equilibrium points and their characteristics, to localize cycles in the phase portraits, to construct stratification of the phase portraits to subdomains with different qualities of trajectory behavior, etc. Such an à priori geometric analysis of the dynamical systems is quite analogous to the basic section “Investigation of functions and plot of their graphs” of Calculus, where the methods of qualitative studies of shapes of curves determined by equations are exposed. In the present paper, we construct ensembles of trajectories in phase portraits of some dynamical systems. These ensembles are 2-dimensional surfaces invariant with respect to shifts along the trajectories. This is analogous to classical construction in analytic mechanics, i. e. the level surfaces of motion integrals (energy, kinetic moment, etc.). Such surfaces compose foliations in phase portraits of dynamical systems of Hamiltonian mechanics. In contrast with this classical mechanical case, the foliations considered in this paper have singularities: all their leaves have a non-empty intersection, they contain limit cycles on their boundaries. Description of the phase portraits of these systems at the level of their stratifications, and that of ensembles of trajectories allows one to construct more realistic gene network models on the basis of methods of statistical physics and the theory of stochastic differential equations.

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Section: And Its Decomposition To Blocksmentioning

confidence: 81%

“…In the domain W 6 1 formed by 12 blocks, from which trajectories can enter one adjacent block only, the Poincaré map contains a unique non-trivial fixed point П 6 * , the trajectory of which is a stable limit cycle for all trajectories in this domain (Golubyatnikov, Minushkina, 2022).…”

Section: And Its Decomposition To Blocksmentioning

confidence: 99%