The dual-drive ball screw pair serves as a crucial element within the fixed gantry machine tool with cross-rail movement. When in service, the dual-drive ball screw pair experiences variations in axial load, impacting the contact load distribution of the ball screw pair. A calculation model for determining the axial load offset of the dual-drive ball screw pair is proposed to investigate the variation in axial load. The impact of the geometric error associated with the guide rail and the position of the slide are considered. This paper presents the contact load distribution model for the dual-drive ball screw pair. This study investigates the contact load and contact angle distribution of the dual-drive ball screw pair during the machine tool in service. Additionally, based on fractal theory, the stiffness models of individual micro-convex body and contact surfaces have been established. This study provides a comprehensive analysis of the contact stiffness of the ball screw pair, considering the influence of guide rail geometric error and slide position. In addition, the three-dimensional surface morphology of ball screw pair is obtained by experiments. This paper investigates the contact stiffness distribution of dual-drive ball screw pair during service.