Fault diagnosis is a complex and fuzzy cognitive process, and soft computing methods as neural networks and fuzzy logic, have shown great potential in the development of decision support systems. Dealing with expert (human) knowledge consideration, Computer-Aided Diagnosis (CAD) dilemma is one of the most interesting, but also one of the most difficult problems. Among difficulties contributing to challenging nature of this problem, one can mention the need of fine classification and decision-making. In this paper, a brief survey on fault diagnosis systems is given first. Then, from a fault diagnosis system analysis of the classification and decision-making problem, a global diagnosis synopsis is deduced. Afterwards, a hybrid intelligent diagnosis approach, based on soft computing implying modular neural networks for classification and fuzzy logic for decision-making, is suggested from signal and image representations. The suggested approach is developed in biomedicine for a CAD, from Auditory Brainstem Response test, and the prototype design and experimental results are presented. In fact, a double classification is exploited in a primary fuzzy diagnosis, to ensure a satisfactory reliability. Then, this reliability is reinforced using a confidence parameter with the primary diagnosis result, exploited in a final fuzzy diagnosis giving the appropriate diagnosis with a Indeed, experimental results demonstrate the efficiency and reliability of CAD for three classes: two auditory pathologies Retro-cochlear Class (RC) and Endocochlear Class (EC), and Normal auditory Class (NC). The generalization rate of NC is clearly higher for primary fuzzy diagnosis and final fuzzy diagnosis than that of the two classifications. The obtained rates for RC and EC are higher than obtained by image classification but quite similar than those obtained by signal classification. An important contribution of the final fuzzy diagnosis is the fact that a confidence index is associated with each fault diagnosis. Finally, a discussion is given with regard to the reliability and large application field of the suggested approach.