In this paper we introduce self-dual cyclic and quantum codes over Z α 2 × (Z2 + uZ2) β . We determine the conditions for any Z2Z2[u]-cyclic code to be self-dual, that is, C = C ⊥ . Since the binary image of a selforthogonal Z2Z2[u]-linear code is also a self-orthogonal binary linear code, we introduce quantum codes over Z α 2 × (Z2 + uZ2) β . Finally, we present some examples of self-dual cyclic and quantum codes that have good parameters.