OnabotulinumtoxinA improves oral aperture in patients with scleroderma: A small clinical trial

González, Catalina; Pamatmat, Jarod John; Burningham, Kevin M.; Yang, Michelle; Goff, Heather W.

doi:10.1016/j.jaad.2023.04.069

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…Reports suggest that hyaluronidase contributes to the prevention and treatment of microstomia in systemic sclerosis or mixed connective tissue disease by hydrolyzing glucosaminidic and glycosidic bonds in hyaluronic acid and other connective tissue mucopolysaccharides [ 50 , 51 ]. Furthermore, improvements in microstomia have been observed in scleroderma patients treated with onabotulinumtoxin A, suggesting that multiple treatment approaches are available [ 52 ].…”

Section: Treatment Of Microstomiamentioning

confidence: 99%

Prevention and treatment of microstomia

Ki,

Park

2024

Arch Craniofac Surg

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The mouth, located in the lower third of the face, is a uniquely visible structure. It serves as a vital organ both aesthetically and functionally, playing a key role in speech, expression, and fundamental oral functions. Consequently, any alterations or defects in its shape, due to various causes, can lead to aesthetic and functional deficiencies. These issues may also result in challenges with social interactions and a decrease in confidence. In cases of microstomia, various surgical approaches are proposed based on the location, extent, shape, and cause of the defect, leading to numerous case reports. Plastic surgeons are proficient in oral reconstruction; however, cases of microstomia are relatively rare, which reduces their familiarity and interest in these cases. Additionally, preferences for oral size and shape vary according to factors such as geographical region and ethnicity, further complicating the functional definition of microstomia. Therefore, both subjective patient and physician judgments play crucial roles in the diagnosis and treatment of microstomia, as these may vary depending on individual and societal aspects. This review aims to classify the various causes and definitions of microstomia, as well as its non-surgical and surgical treatment options, with the goal of the treatment of this condition.

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Section: Treatment Of Microstomiamentioning

confidence: 99%