Once daily dosing of aminoglycoside: one step forward

Adaptive resistance following single doses of gentamicin in a dynamic in vitro model

“…During 1989 to 1992, several reviews on this subject appeared (7,15,22,24,28,30,36) and clinical trials suggest either equal or improved efficacy of once daily dosing compared with multidose 20 23 28 30 regimens and equal or less renal toxicity and ototoxicity (1, 8, lla, 13, 14, 18, 19, 23, 29, 31-34, 37, 38, 40, 41 …”

Pharmacokinetic profile of once daily intravenous tobramycin in children with cystic fibrosis

“…[1][2][3][4][5][6] However, there are some theoretical advantages of once-daily dosing with higher peak levels and the potential for improved bacterial killing. [7][8][9][10] Aminoglycosides are frequently used for the treatment of pulmonary exacerbations in patients with cystic fibrosis (CF) who are antibiotic. Tobramycin was given at a dose of 12 mg/kg body weight (admission weight), diluted to 100 mL with normal saline and infused over half an hour.…”

“…This has been principally because of the convenience as well as theoretical reduction in ototoxicity and nephrotoxicity 1–6 . However, there are some theoretical advantages of once‐daily dosing with higher peak levels and the potential for improved bacterial killing 7–10 …”

Exposure Effects of Netilmicin on <i>Enterobacter cloacae </i>Clinical Isolates

“…It has been recently suggested that, in gram-negative bacteremia, single daily admin istration might be more efficacious than mul tiple daily dosage of an AMG [13], The once daily regimens result in high peak serum con centration of the antibiotic [14,15]. We show here that exposure to achievable in vivo con centrations of netilmicin exerts significant ef fects on essential virulence characteristics of E. cloacae.…”