Once-daily feeding is associated with better health in companion dogs: Results from the Dog Aging Project

Ee, Bray; Zheng, Zihan; Tolbert, M Katherine; Bm, McCoy; Kaeberlein, Matt; Kerr, KF

doi:10.1101/2021.11.08.467616

Cited by 6 publications

(7 citation statements)

References 63 publications

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“…The complete survey data from this group comprises Release 1.0 of the DAP dataset, which is publicly available. Data summaries can be found at https://data.dogagingproject.org , as well in recently published studies on the dataset ( 29 , 30 ). Briefly, dogs were 7.28 years old on average and weighed 23 kg with 27.3% of dogs having been classified as ever overweight.…”

Section: Resultsmentioning

confidence: 99%

Demographic factors associated with joint supplement use in dogs from the Dog Aging Project

Hoffman

Tolbert²,

Promislow³

2022

Front. Vet. Sci.

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Osteoarthritis (OA) is one of the most prevalent age-related chronic conditions that afflict companion dogs, and multiple joint supplements are available to prevent or treat OA, though the efficacy of these treatments is controversial. While the demographic factors that are associated with OA diagnosis are well established, the factors that are associated with joint supplement use are not as well studied. Using data collected from the Dog Aging Project, we analyzed owner survey responses regarding joint supplement administration and OA diagnosis for 26,951 adult dogs. In this cross-sectional analysis, logistic regression models and odds-ratios (OR) were employed to determine demographic factors of dogs and their owners that were associated with joint supplement administration. Forty percent of adult dogs in our population were given some type of joint supplement. Perhaps not surprisingly, dogs of older age, larger size, and those that were ever overweight were more likely to receive a joint supplement. Younger owner age, urban living, owner education, and feeding commercial dry food were associated with a reduced likelihood of administration of joint supplements to dogs. Interestingly, mixed breed dogs were also less likely to be administered a joint supplement (OR: 0.73). Dogs with a clinical diagnosis of OA were more likely to receive a joint supplement than those without a reported OA diagnosis (OR: 3.82). Neutered dogs were more likely to have a diagnosis of OA, even after controlling for other demographic factors, yet their prevalence of joint supplement administration was the same as intact dogs. Overall, joint supplement use appears to be high in our large population of dogs in the United States. Prospective studies are needed to determine if joint supplements are more commonly administered as a preventative for OA or after an OA clinical diagnosis.

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Section: Resultsmentioning

confidence: 99%

Demographic factors associated with joint supplement use in dogs from the Dog Aging Project

Hoffman

Tolbert²,

Promislow³

2022

Front. Vet. Sci.

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“…Similarly, pharmacological longevity interventions, such as via metformin administration (a non-specific AMPK activator (Pernicova and Korbonits, 2014)), produces trending male-specific longevity effects (https://phenome.jax.org/projects/ITP1). Exploring sex differences in longevity is feasible in other vertebrate models, including dogs (Bray et al, 2021; Creevy et al, 2022), and could be further examined in human clinical trials (Barzilai, 2017; Kulkarni et al, 2020). Thus, better understanding the molecular mechanisms behind sex-specific longevity differences could provide unique opportunities for manipulating health and disease.…”

Section: Discussionmentioning

confidence: 99%

“…For example, administration of metformin, which interacts with mitochondrial complex I (and is a non-specific AMPK activator (Pernicova and Korbonits, 2014)), produces trending male-specific longevity bias as seen in the Intervention Testing Program (ITP, https://phenome.jax.org/projects/ITP1). This approach is now expanded for other models, including dogs, which represent an exciting model for aging (Bray et al, 2021; Creevy et al, 2022). However, the molecular mechanisms behind these longevity differences are largely unknown (Austad, 2011; Austad and Fischer, 2016), and could provide exciting opportunities for manipulating health and disease.…”

Section: Discussionmentioning

confidence: 99%

Sex-specific regulation of metabolic health and vertebrate lifespan by AMP biosynthesis

Astre

Atlan

Goshtchevsky

et al. 2022

Preprint

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The loss of energy homeostasis seen during aging, is causally linked to multiple age-related pathologies. The AMP-activated protein kinase (AMPK) directly senses cellular energy levels, which are reflected in the ratio between AMP:ATP. However, the genetic regulation of vertebrate aging by the AMPK pathway remains poorly understood. Here, we manipulate ATP production by mutating APRT, a key enzyme in AMP biosynthesis, and extend vertebrate lifespan in a male-specific manner. Using a multi-omics approach, we demonstrate that the APRT mutation restores metabolic plasticity, and identify a distinct transcriptional signature linking mitochondria with the sex-related differences in longevity. Accordingly, APRT mutant cells display a reduction in mitochondrial functions and ATP levels, and an increase in AMPK activity, resembling a persistent state of energy starvation. In-vivo, a fasting-like response was observed exclusively in male mutants, including resistance to a high-fat diet. Finally, intermittent fasting eliminated the longevity benefits mediated by the APRT mutation in males. Together, these data identify AMP biosynthesis as a sex-specific mediator of vertebrate longevity and metabolic health.

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“…If dogs received omega 3, vitamins, probiotics, antioxidants, taurine, carnitine, and/or coenzyme Q10 daily, they were considered ‘affected’ in the neuroprotective supplement category (Heath, Barabas, & Craze, 2007; Mad’ari, Farbakova, & Žilka, 2017; Milgram et al, 2004; Pan, Kennedy, Jönsson, & Milgram, 2018). Finally, we also created a variable accounting for whether a dog had a history of training (Bray et al, 2022), given intriguing preliminary evidence that this sort of enrichment is linked to delay in cognitive decline (Bray et al, 2022; Milgram, Siwak-Tapp, Araujo, & Head, 2006; Szabó et al, 2018). Training history was determined according to what the owner reported as the dog’s primary or secondary activity (e.g., service dogs, agility dogs, and dogs trained for field trials vs. pets/companion; see SI 1, Appendix B for full details).…”

Section: Methodsmentioning

confidence: 99%

Associations between physical activity and cognitive dysfunction in older companion dogs: Results from the Dog Aging Project

Bray

Raichlen

Forsyth

et al. 2022

Preprint

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Canine Cognitive Dysfunction (CCD) is a form of dementia that shares many similarities with Alzheimer’s disease. Given that physical activity is believed to reduce risk of Alzheimer’s disease in humans, we explored the association between physical activity and cognitive health in a cohort of companion dogs, aged 6-18 years. We hypothesized that higher levels of physical activity would be associated with lower (i.e., better) scores on a cognitive dysfunction rating instrument and lower prevalence of dementia, and that this association would be robust when controlling for age, comorbidities, and other potential confounders. Our sample included 11,574 companion dogs enrolled through the Dog Aging Project, of whom 287 had scores over the clinical threshold for CCD. In this observational, cross-sectional study, we used owner-reported questionnaire data to quantify dog cognitive health (via a validated scale), physical activity levels, health conditions, training history, and dietary supplements. We fit regression models with measures of cognitive health as the outcome, and physical activity—with several important covariates—as predictors. We found a significant negative relationship between physical activity and current severity of cognitive dysfunction symptoms (estimate = -0.10, 95% CI: -0.11 to - 0.08, p < 0.001), extent of symptom worsening over a 6-month interval (estimate = -0.07, 95% CI: -0.09 to -0.05, p <0.001), and whether a dog reached a clinical level of CCD (odds ratio = 0.53, 95% CI: 0.45 to 0.63, p <0.001). Physical activity was robustly associated with better cognitive outcomes in dogs. Our findings illustrate the value of companion dogs as a model for investigating relationships between physical activity and cognitive aging, including aspects of dementia that may have translational potential for Alzheimer’s disease. While the current study represents an important first step in identifying a relationship between physical activity and cognitive function, it cannot determine causality. Future studies are needed to rule out reverse causation by following the same dogs prospectively over time, and to evaluate causality by administering physical-activity interventions.

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Once-daily feeding is associated with better health in companion dogs: Results from the Dog Aging Project

Cited by 6 publications

References 63 publications

Demographic factors associated with joint supplement use in dogs from the Dog Aging Project

Demographic factors associated with joint supplement use in dogs from the Dog Aging Project

Sex-specific regulation of metabolic health and vertebrate lifespan by AMP biosynthesis

Associations between physical activity and cognitive dysfunction in older companion dogs: Results from the Dog Aging Project

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